Registration Dossier
Registration Dossier
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EC number: 225-202-8 | CAS number: 4712-55-4
Endpoint summary
Administrative data
Description of key information
Assessment of Aquatic Toxicity Based on Assessment of Hydrolysis Products
Based on experiences with attempting to design and conduct appropriate studies to investigate the ecotoxicity of alkyl and aryl phosphites, it was determined that conducting aquatic toxicity studies on diphenyl phosphonate (DPP) in algae, daphnia and fish would not be possible. This conclusion is consistent with OECD Guidance Document #23 entitled “Guidance Document on Aquatic Toxicity Testing of Difficult Substances and Mixtures” (OECD 2000) because of the inherent physical/chemical properties of the test substance (i.e. poor water solubility and hydrolysis). Based on the expert approach that was developed for alkyl and aryl phosphites, it was concluded that, since direct measurements of the ecotoxicity of the parent test substance (DPP) would not feasible, the evaluation should focus on quantifying the toxicity of the combination of hydrolysis by-products of DPP – namely phenol and phosphorus acid.
Phenol is classified as Aquatic Chronric 2 (H411) and thus this classification has been applied to DPP. This phenol classification is expected to be the most relevant aquatic classification for DPP. An additional classification of Aquatic Acute 1 (H400) was added based on preliminary ECOSAR acute results that were later determined to be based on modelling of the incorrect structure. The SMILES code used for the preliminary modelling was OP(Oc1ccccc1)(Oc2ccccc2), when it should have been O=P(Oc1ccccc1)(Oc2ccccc2). The modelled data on the proper structure does not indicate a need for the Aquatic Acute 1 classification.
Phosphorus acid is not considered hazardous to the environment.
Additional information
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