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EC number: 231-185-8 | CAS number: 7443-25-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute aquatic toxicity
Algae: 72h-EC50 (Desmodesmus subspicatus, growth rate) = 9.3 mg/L, 72h-EC10 (Desmodesmus subspicatus, growth rate) = 0.963 mg/L (nominal)
Daphnia: 48h-EC50 (Daphnia magna, immobilisation) = 1.68 mg/L, 48h-NOEC (Daphnia magna, immobilisation) = 1.25 mg/L; 48h-LOEC (Daphnia magna, immobilisation) = 2.50 mg/L (nominal)
Fish: 96-LC50 (Danio rerio) > 1.23 mg/L (geom. mean measured)
STP microorganisms
3h-EC10 (activated sludge, total respiration inhibition) = 33.7 mg/L, 3h-EC50 (activated sludge, total respiration inhibition) > 1000 mg/L (nominal)
Additional information
Acute aquatic toxicity
Toxicity studies for the submission substance were available for three trophic levels, i.e. algae, daphnia and fish. The most sensitive organisms were aquatic invertebrated (Daphnia magna). All studies were considered reliable and adequate for the environmental hazard assessment for aquatic organisms.
Algae
In a reliable key study, toxicity of the submission substance to the green alga was determined according to OECD 201 (2011) and in compliance with GLP (RL1). The study was conducted with five test concentrations (nominal 0.0632, 0.200, 0.632, 2.00, 6.32 and 20.0 mg/L) under static conditions during 72 hours. Adverse effects on growth rate and yield of biomass followed a dose-response relationship. Derived effect concentrations on growth rate (r) and yield of biomass (y) were (nominal): 72h-ErC50 = 9.30 mg/L, 72h-ErC10 = 0.963 mg/L (OECD 201, 2017), 72h-NOErC = 0.632 mg/L; 72h-EyC50 = 1.11 mg/L, 72h-NOEyC = 0.200 mg/L (EC10 was not derived for yield of biomass).
Daphnia
In a reliable key study, acute immobilisation of Daphnia magna caused by the submission substance was determined according to OECD 202 (2004) and in compliance with GLP (RL1). The study was conducted with five test concentrations (nominal 10, 5, 2.50, 1.25, 0.625 mg/L) under static test conditions during 48 hours. The test concentrations and control were analytically verified by HPLC-DAD analysis. Observed effects followed a dose-response relationship with no effect the lowest test concentration (0.625 mg/L), first occurrence of immobilisation at 1.25 mg/L and complete immobilisation at highest tests concentration (10 mg/L). Derived effect concentrations were (nominal): 48h-EC50 = 1.68 mg/L (95 % confidence limits: 1.38 - 2.05 mg/L), 48h-NOEC = 1.25 mg/L and 48h-LOEC = 2.50 mg/L.
Fish
Acute toxicity of the submission substance to fish (zebrafish) was determined according to the OECD 203 (1992) and in compliance with GLP (RL1). A nominal test concentration of 2.00 mg/L (corresponding to 1.23 mg/L geom. mean measured) was tested as a threshold concentration in a limit test under semi-static conditions during 96 hours. No mortality or sublethal effects were observed in the treatment group or control during exposure. The derived effect concentrations were therefore: 96h-LC50 > 1.23 mg/L, 96h-NOEC > 1.23 mg/L.
STP microorganisms
In a reliable key study, respiration inhibition of the submission substance on activated sludge was investigated according to OECD 209 and in compliance with GLP (RL1). The test was carried out with five test concentrations (3.2 - 10 - 32 - 100 - 320 - 1000 mg/L) under static conditions for three hours. Inhibition of total respiration followed a dose-response relationship. The submission substance was not toxic up to a concentration of >= 10 mg/L. The determined NOEC was therefore 10 mg/L. Further calculated effect concentrations were (nominal): EC10 = 33.7 mg/L, EC20 = 68.5 mg/L, EC50 / EC80 > 1000 mg/L. The study was considered reliable and adequate for the environmental hazard assessment for STP microorganisms.
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