Registration Dossier
Registration Dossier
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EC number: 231-185-8 | CAS number: 7443-25-6
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other: expert statement
Reference
Description of key information
There are no studies available in which the toxicokinetic properties of the substance were investigated.
The test item, an organic substance, which is solid (white powder) at room temperature is weakly hydrolytically unstable and hydrolyses within several days, depending on the pH value (see IUCLID chapter 5.1.2). The substance is slightly water solube (91 mg/L; see IUCLID chapter 4.8). The octanol water partition coefficient (Log Pow) for the substance was determined to be 2.4 (see IUCLID chapter 4.7).
Absorption
With reference to the slight solubility in water, its molecular weight below 500 and a Log Pow of 2.4 absorption of the substance has principally to be considered (please refer to ECHA Guidance on information requirements and chemical assessment, R.7c, Table R.7.12-1, (V3.0; 2017, p. 181)). Also the observation that the substance is not ionisable strengthens the conclusions that the substance can principally be absorbed (please refer to ECHA Guidance on information requirements and chemical assessment, Chapter R.7c, p. 167). This assumption is especially strengthened by the results of a Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test (OECD 422): NOAEL 300 mg/kg bw/d (adverse changes only observed in highest dose group). These data indicate that some amounts of the substance are bioavailable.
Distribution
Taking into account the slight water solubility of the substance as well as its Log Pow value it can be assumed that it will migrate into cells and concentration in adipose tissues or other systemic compartments cannot be ruled out (please refer to ECHA Guidance on information requirements and chemical assessment, Chapter R.7c, pp. 176-177).
Metabolism
There is no information on the metabolism of the substance. But hydrolysis of the ester and ether groups as well as ring hydroxylation seems to be possible mechanisms.
Excretion
With reference to the slight solubility of the substance as well as its low molecular weight urinary excretion might be considered as the most favorable excretion route. (please refer to ECHA Guidance on information requirements and chemical assessment, Chapter R.7c, p. 178).
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
none
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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