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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

Source substance Phosphorodithioic acid, mixed O,O-bis(1,3 -dimethylbutyl and iso-Pr) esters, zinc salts (CAS 84605 -29 -8):

The acute toxicity of the test material to the freshwater fish Oncorhynchus mykiss was investigated under GLP according to OECD guideline 203 in a Klimisch-2 study and resulted in a 96 hour LL50 of 4.5 mg/L (95% confidence limits of 3.5 to 5.7 mg/L) and a NOEL of 1.8 mg/L.

Source substance Zinc bis(O,O-diisobutyl dithiophosphate) (CAS 68457 -79 -4):

The acute toxicity of the test material to the saltwater fish Cyprinodon variegatus was investigated under GLP according to OECD guideline 203 in a Klimisch-2 study and resulted in a 96 hour LC50 of 46 mg/L. A reference toxicity test was conducted with sodium lauryl sulfate resulting in a 96 hour LC50 of 1.3 mg/L.

Source substance Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (CAS 4259 -15 -8):

The acute toxicity of the test material to the freshwater fish Oncorhynchus mykiss was investigated under GLP according to OECD guideline 203 in a Klimisch-2 study and resulted in a 96 hour LL50 of 4.4 mg/L (95% confidence limits of 4.4 to 4.6 mg/L) and a NOEL of 3.2 mg/L

The LL50 -values for the acute toxicity to freshwater fish are slightly differing (4.5 & 4.4 mg/L), but this is in range with the category approach, where nevertheless the members of one category may have different values.

For CSA the lower value is choosen as worst-case-approach .

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Dose descriptor:
LC50
Effect concentration:
4.4 mg/L

Marine water fish

Marine water fish
Dose descriptor:
LC50
Effect concentration:
46 mg/L

Additional information

The key value for the CSA for freshwater fish is stated as LL50, not as LC50!