Registration Dossier
Registration Dossier
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EC number: 214-482-7 | CAS number: 1134-23-2
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- QSAR
- Justification for type of information:
- The acute toxicity on fish QSAR prediction was assessed as adequate for regulatory purposes (Klimisch 2 – results derived from a valid QSAR model and falling into its applicability domain, with adequate and reliable documentation/justification)
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- QSAR
- GLP compliance:
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 19 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Remarks:
- QSAR
- Basis for effect:
- not specified
- Remarks:
- QSAR
- Details on results:
- See it in the attached full QSAR report.
- Validity criteria fulfilled:
- yes
- Conclusions:
- QSAR Prediction 96-h LC50 (Pimephales promelas) equal to 19 mg/L.
It is highlighted that the target Cycloate is included in the training set of the model, and for which an experimental 96-h LC50 value on Pimephales promelas equal to 28 mg/L is
reported. In addition, experimental 96-h LC50 data on fish (Lepomis macrochirus – Bluegill, and Oncorhynchus mykiss - Rainbow Trout) in the range 4.5 – 7.0 mg/L are available (U.S.
EPA Pesticide Ecotoxicity Database). - Executive summary:
QSAR Prediction 96-h LC50 (Pimephales promelas) equal to 19 mg/L
Reference
Description of key information
LC50 freshwater fish
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 4.5 mg/L
Additional information
cycloate: LC50 freshwater fish acute toxicity short term toxicity = 4.5 mg/l
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