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EC number: 214-482-7 | CAS number: 1134-23-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
- Endpoint:
- carcinogenicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This animal study is not performed according to GLP, but the test parameters are well documented and scientifically acceptable.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- EPA Pesticide Assessment Guidelines- Subdivision F, Hazard Evaluation-Human and domestic animals, Revised edition. U.S. Environmental Protection Agency, Washington, D.C., 1984
- GLP compliance:
- no
Test material
- Reference substance name:
- CAS 1134-23-2
- IUPAC Name:
- CAS 1134-23-2
- Details on test material:
- 97.6 % cycloate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- A vizsgálathoz szükséges SPF Wistar törzsű hím és nőstény állatokat a LATI Közös Vállalatól szerezték be 4 hetes korban. A vizsgálatot 6 hetes állatokon kezdték el.
Az állatokat klimatizált, jól szellőztetett állatszobában, II. típ. állattartó edényben helyezték el, száraz, vegyes faforgács almon. Az állatházban fényprogram alapján 12-12 órás megvilágítást, illetve sötétséget, 21 +- 2 C hőmérsékletet biztosítottak. A légtér relatív páratartalma legalább 40-50% volt.
A viszgálatba vont állatok standard LATI patkánytápt és csapvizet ad libitum fogyasztottak.
Administration / exposure
- Route of administration:
- oral: feed
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- not specified
- Details on exposure:
- 0,19,41,75 mg/100g feed
- Details on analytical verification of doses or concentrations:
- Packard 419 type Gas chromatography was used for analytical verification.
Hőmérséklet inj: 190 C
kolonna: 165 C
detektor: 220 C
töltet: 10% SE-52 Chromosorb WAW DMCS 80-100 mesh
oszlophossz: 1m, belső átmérő: 2mm
vivőgáz: nitrogén, hidrogén és levegő mennyisége, detektor optimum szerint - Duration of treatment / exposure:
- 2 years, but We could find results until 18 months, end of the study results of until 24 months is missing.
- Frequency of treatment:
- daily feeding
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0 mg/kg bw/day (actual dose received)
- Dose / conc.:
- 10 mg/kg bw/day (actual dose received)
- Dose / conc.:
- 21 mg/kg bw/day (actual dose received)
- Dose / conc.:
- 39 mg/kg bw/day (actual dose received)
- No. of animals per sex per dose:
- 15 male and 15 female
- Control animals:
- yes
Examinations
- Observations and examinations performed and frequency:
- szemvizsgálat, túlélés, viselkedés, testtömeg és takarmány/víz-fogyasztás, vizeletvizsgálat, hematológiai vizsgálat, klinikai kémiai vizsgálatok, kórbonctani vizsgálat, szervtömeg mérés, kórszövettani vizsgálat,
- Sacrifice and pathology:
- Kóronctani vizsgálat: minden állatot (CO2-vel történt túlaltatás után) feldolgoztak. A makroszkópikus megfigyelés kiterjedt az általános erőnléti állapotra, testnyílásokra, a kültakaróra és a belső szervekre. Az esetleges elváltozásokat feljegyezték.
- Statistics:
- z egyes dóziscsoportban számított, mért adatok kontrolltól való eltérésének statisztikai ellenőrzésére a Student-féle t-próbát alkalmaztuk. A varinacia homogenitás vizsgálatára a Bartlett próbát vettük igénybe.
Results and discussion
Effect levels
- Key result
- Remarks on result:
- not determinable
- Remarks:
- We could find results until 18 months, end of the study results of until 24 months is missing.
Applicant's summary and conclusion
- Conclusions:
- A tervszerűen boncolt állatok csoportjainak kezelt egyedeiben daganatos elváltozás halmozódását vagy a gyakoriság növekedését kimutatni nem tudták.
Cycloat is reported to be not carcinogen after 18 months of examination. We could find results until 18 months, end of the study results of until 24 months is missing. - Executive summary:
A tervszerűen boncolt állatok csoportjainak kezelt egyedeiben daganatos elváltozás halmozódását vagy a gyakoriság növekedését kimutatni nem tudták.
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