Phenol, mono- + distyrenated (MSP+DSP)

Surface tension

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

surface tension

Type of information:

experimental study

Adequacy of study:

key study

Study period:

01-06.12.2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 115 (Surface Tension of Aqueous Solutions)

Qualifier:

according to guideline

Guideline:

EU Method A.5 (Surface Tension)

GLP compliance:

yes (incl. QA statement)

Type of method:

OECD harmonised ring method

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: RÜTGERS Germany GmbH, Varziner Strasse 49, 47138 Duisburg (Germany)
- Lot/Batch n°: Lab Sample 18.9.2017
- Expiration date of the lot/batch: 31-12-2018
- Purity test date: 18-09-2017

Key result

Surface tension:

48.45 mN/m

Temp.:

20 °C

Conc.:

90 other: % saturated solution

Determination of the density

The buoyancy method yielded a density of the test solution of 1.004 g/cm³ at 20.0°C. The density was used for the correction method of Harkins and Jordan in the determination of the surface tension.

Temperature

The temperature of the test solution during the whole series of measurements was between 19.9 and 20.0°C.

Time line of the surface tension determination

Start of measurement was 27.1 minutes after transfer of the test solution into the vessel. After that time, 15.2 minutes were needed to reach equilibrium at which 10 successive measurements were successfully achieved with a standard deviation of <= 0.05 mN/m.

Surface tension of the test item

Measurement No. ^1)	Time ^2) (min)	Time ^3) (min)	Surface Tension (mN/m)	Temperature (°C)
1	36.13	9.01	48.39	20.0
2	36.83	9.71	48.41	20.0
3	37.54	10.42	48.41	20.0
4	38.25	11.13	48.44	20.0
5	38.96	11.84	48.44	20.0
6	39.65	12.53	48.44	20.0
7	40.33	13.21	48.49	20.0
8	40.98	13.86	48.50	20.0
9	41.75	14.64	48.51	20.0
10	42.41	15.29	48.52	20.0
Mean	-	-	48.45	20.0
SD (+/-)	-	-	0.05	0.0

SD = standard deviation

¹⁾ of the last 10 measurements

²⁾ Time from transfer of the test solution into test vessel until end of each measurement

³⁾ Time start of measurement until end of each measurement

Conclusions:

The surface tension of a 90% saturated aqueous solution of the test item 4-(1-phenylethyl)phenol was determined to be 48.45 mN/m (SD +/- 0.05 mN/m) at 20°C.

Executive summary:

The test was performed to determine the surface tension of an aqueous solution with a concentration of 90% of the saturation concentration of the test item 4-(1-phenylethyl)phenol via tensiometer using the OECD-harmonised ring method. The study was performed according to OECD TG 115, EU Method A.5 and in compliance to GLP.

The density of the test solution was determined in a preliminary measurement via the buoyancy method to be 1.004 g/cm3 (20.0°C).

The temperature of the test solution during the whole series of measurements was between 19.9 and 20.0°C, and the validity criteria for the test were fulfilled.

The determination was carried out with a tensiometer in ten successive measurements (SD ≤ 0.05 mN/m).

The surface tension of a 90% saturated aqueous solution of the test item was determined to be 48.45 mN/m (SD +/- 0.05 mN/m) at 20°C.

Considering that distilled water has a surface tension of 72.75 mN/m at 20°C and the test item showed a surface tension below 60 mN/m under the conditions of this test method, the test item should be regarded as being surface-active material.

Reference 2

Endpoint:

surface tension

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Justification for type of information:

1. HYPOTHESIS FOR THE ANALOGUE APPROACH
Approx. 20 % of the target compound, the registration substance phenol, styrenated, accounts for the source substance, 4-styrenated derivative of phenol, 4-(1-phenylethyl)phenol, and thus is assumed to represent the low-molecular fraction in the target mixture, that may have some amphiphilic properties. Its stretched chemical structure suggests that it will have the highest surface activity - if at all - of the monostyrenated phenol fraction.
Surface activity is not considered relevant for the target compound, however was meant to be a pre-exercise for the determination of the log Pow.

2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
not relevant (see 1. above)
The source compound is a position-isomer of monostyrenated phenol with the substituent, 1-phenylethyl or α-monomethylbenzyl, in the para-position of the central phenol ring. In the target substance, the registration substance phenol, styrenated, the isomer is present at a substantial amount of about 35 to 55 %, in total approx. 50 to 70 % including the 2-styrenated isomer with about 10 to 25 %. The remainder of the target compound is represented by the di-tyrenated phenol, 2,4-(1-phenylethyl-)phenol, with about 20 to 40 %, and tri-styrenated phenol, 2,4,6-(1-phenylethyl-)phenol, with a minor amount of about 0.2 to 5 %.

3. ANALOGUE APPROACH JUSTIFICATION
not relevant (see 1.above)

Reason / purpose for cross-reference:

read-across source

Principles of method if other than guideline:

Read-across to preceding entry:
Source test material: 4-(1-phenylethyl)phenol;
Reference: Thieu 2018

Key result

Surface tension:

48.45 mN/m

Temp.:

20 °C

Conc.:

90 other: % saturated solution

Description of key information

The surface tension of 4-(1-phenylethyl)phenol (4 -MSP) was determined by means of a tensiometer using the OECD-harmonized ring method in accordance with OECD Guidance 115 and EU method A.5.

The surface tension of a 90 % saturated aqueous solution of the test item was determined to be 48.45 mN/m (SD ± 0.05 mN/m) at 20°C. As the surface tension value is below the threshold of 60 mN/m under the conditions of this test method, the test item should be regarded as having some surface active potential.

Key value for chemical safety assessment

Surface tension:

48.45