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EC number: 700-672-1 | CAS number: 70226-26-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: National guideline study with acceptable restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: "Appraisal of the safety of chemicals in foods, drugs and cosmetics" by the Staff of the Division of Pharmacology, FDA, according to Draize (1959)
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,3-dihydroxypropyl laurate
- EC Number:
- 205-526-6
- EC Name:
- 2,3-dihydroxypropyl laurate
- Cas Number:
- 142-18-7
- Molecular formula:
- C15H30O4
- IUPAC Name:
- 2,3-dihydroxypropyl laurate
- Details on test material:
- - Name of test material (as cited in study report): only trade name given
- Physical state: crystalline solid substance
- Analytical purity: no data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.4-2.6 kg
- Housing: animales were housed individually
- Diet: standard diet (Höing 222), ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18
- Humidity (%): 50-60
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the untreated eye served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 g - Duration of treatment / exposure:
- single application without washing
- Observation period (in vivo):
- 7 days
Reading time points: 1, 2, 8, 24, 48 and 72 h and 4, 5, 6 and 7 days - Number of animals or in vitro replicates:
- 6
- Details on study design:
- SCORING SYSTEM: Draize scoring system
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- out of all 6 animals
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72-96 h
- Remarks on result:
- other: individual mean scores ranged from 0 to 1.0
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- out of all 6 animals
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: reversibility: not applicable
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- out of all 6 animals
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 1.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h - 6 days
- Remarks on result:
- other: individual mean scores ranged from 0.3 to 2.0
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- out of all 6 animals
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h - 6 days
- Remarks on result:
- other: individual mean scores ranged from 0.3 to 1.7
- Irritant / corrosive response data:
- At the 1, 2 and 8 h reading time points, no corneal opacity and no iritis were observed in any animal. Whereas at this time points, slight to moderate conjunctival redness and moderate to strong chemosis and discharge were seen in all animals (see Table 2 under “Any other information on results incl. tables”). In 2/6 animals corneal opacity was observed and was fully reversible within 48 h and 72 h, respectively.
No effects on the iris were observed in any animal during the study period.
Slight to moderate conjunctival redness was observed in all animals 24 h post-instillation being fully reversible within 48 h (2 animals), 72 h (1 animal) and 5 days (3 animals).
24 h post application, slight to strong discharge was observed in all animals. Effects were fully reversible within 72 h in 5 animals and 4 days (1 animal). - Other effects:
- No further local or systemic effects were reported.
Any other information on results incl. tables
Table 1. Results of eye irritation study.
Rabbit number # |
Time [h] |
conjunctivae score
|
iris |
cornea |
|
|
|
redness |
swelling |
|
|
1 |
1 |
1 |
2 |
0 |
0 |
|
24 |
2 |
1 |
0 |
0 |
|
48 |
2 |
1 |
0 |
0 |
|
72 |
1 |
1 |
0 |
0 |
|
average |
1.7 |
1.0 |
0.0 |
0.0 |
2 |
1 |
1 |
2 |
0 |
0 |
|
24 |
2 |
1 |
0 |
0 |
|
48 |
1 |
1 |
0 |
0 |
|
72 |
1 |
1 |
0 |
0 |
|
average |
1.3 |
1.0 |
0.0 |
0.0 |
3 |
1 |
1 |
2 |
0 |
0 |
|
24 |
2 |
2 |
0 |
0 |
|
48 |
1 |
1 |
0 |
0 |
|
72 |
0 |
0 |
0 |
0 |
|
average |
1.0 |
1.0 |
0.0 |
0.0 |
4 |
1 |
1 |
3 |
0 |
0 |
|
24 |
1 |
1 |
0 |
0 |
|
48 |
0 |
0 |
0 |
0 |
|
72 |
0 |
0 |
0 |
0 |
|
average |
0.3 |
0.3 |
0.0 |
0.0 |
5 |
1 |
1 |
2 |
0 |
0 |
|
24 |
2 |
1 |
0 |
1 |
|
48 |
2 |
1 |
0 |
1 |
|
72 |
2 |
1 |
0 |
1 |
|
average |
2.0 |
1.0 |
0.0 |
1.0 |
6 |
1 |
2 |
2 |
0 |
0 |
|
24 |
2 |
2 |
0 |
1 |
|
48 |
2 |
2 |
0 |
1 |
|
72 |
1 |
1 |
0 |
0 |
|
average |
1.7 |
1.7 |
0.0 |
0.7 |
|
|
|
|
|
|
|
Time [h] |
conjunctivae score |
iris |
cornea |
|
|
|
redness |
swelling |
|
|
average scores |
1 |
1.17 |
2.17 |
0.00 |
0.00 |
24 |
1.83 |
1.33 |
0.00 |
0.33 |
|
48 |
1.33 |
1.00 |
0.00 |
0.33 |
|
72 |
0.83 |
0.67 |
0.00 |
0.17 |
|
|
24+48+72 |
1.33 |
1.00 |
0.00 |
0.28 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: not classified
DSD: not classified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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