Registration Dossier
Registration Dossier
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EC number: 244-344-1 | CAS number: 21351-79-1
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
Waiver:
In accordance with column 2 of REACH Regulation EC (No) 1907/2006 Annex VII, section 8.3, the skin sensitisation study does not need to be conducted as cesium hydroxide monohydrate and cesium hydroxide anhydrous are corrosive to the skin due to their strong basic character (pH > 11.5).
Supporting study:
In a dermal sensitization study with cesium hydroxide (0.1 %) in water, young adult male albino guinea pigs (in total 15 animals) were tested using the method of Landsteiner and Jacobs (1935). The test compound was administered intradermally three times a week, for a total of nine treatments. Following a two-week period with no further injections a challenge of 0.1% was administered the same way. There was no evidence of erythema, swelling or discoloration of the test sites after each of the nine sensitizing cutaneous injections or after the challenge dose. These results indicate that cesium hydroxide did not induce cutaneous sensitisation in guinea pigs.
Justification for selection of skin sensitisation endpoint:
In accordance with column 2 of REACH Regulation EC (No) 1907/2006 Annex VII, section 8.3, the skin sensitisation study does not need to be conducted as cesium hydroxide monohydrate and cesium hydroxide anhydrous are corrosive to the skin due to the strong basic character (pH > 11.5).
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
The test substance is considered to have skin corrosive properties based on its strong basic character.
Justification for classification or non-classification
Due to the skin corrosive properties and based on the results obtained from the supporting study, neither cesium hydroxide monohydrate nor cesium hydroxide anhydrous were classified and labelled according to Regulation (EC) No 1272/2008 (CLP) with regard to sensitisation properties.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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