Registration Dossier
Registration Dossier
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EC number: 240-759-7 | CAS number: 16712-64-4
Endpoint summary
Administrative data
Description of key information
Additional information
Three acute and one long-term study are available for the structural analog of 6 -HNA, 3 -HNA. The most critical endpoint was derived from a study with Pseudokirchneriella subcapitata with a 72 -hour NOEC for growth rate of 7.21 mg/L. To show that the results derived from the studies with 3 -HNA are suitable for the use as a surrogate for 6 -HNA, a QSAR modelling was conducted for 3 -HNA as well as for 6 -HNA. The results showed a higher toxicity of 3 -HNA than of 6 -HNA for all test species. It is therefore justified to use the data of the 3 -HNA studies for read-across to 6 -HNA, as they represent a worst-case situation. Thus, the NOEC derived from the algae study was chosen for the PNEC calculation.
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