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Diss Factsheets
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EC number: 938-828-8 | CAS number: 1463474-95-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
HBED-Fe is not expected to be harmful to aquatic organisms based on read across from EDDHMA-Fe (structural analogue). This is confirmed by the results observed in the long term daphnia test with HBED-Fe where no effects upto 96.6 mg a.i./L were observed for reproduction or parental mortality.
The results as observed for algae should be considered with case due to the chelating properties and coloration of the test solutions.
Additional information
Not all data are available for the substance itself, however sufficent reliable data are also available from structurally similar substances and the actual test substance to allow a conclusion on the ecotoxicity of HBED-Fe (see also read across justification in section 13 of IUCLID).
Fish:
The acute toxic effects of EDDHMA-Fe to fish were investigated in studies according to the principles of OECD-Guideline 203 and EU method C.1. The LC50 for a 96 hour exposure was greater than 1000 mg/L for rainbow trout and carp.
Daphnia:
The acute toxic effects of EDDHMA-Fe (a structurally similar material as HBED-Fe) to Daphnia magna were investigated according to the principles of OECD-Guideline 202 and EU method C.2. The EC50 for a 48 hour exposure was 4.6 g/L.
In a long-term daphnia study according to OECD 211 with EDDHMA-Fe, no effects on the survival of Daphnia magna at concentrations up to and including 1000 mg/L were observed. In the same study a NOEC of 320 mg/L for reproduction could be derived.
As bridging study a long term daphnia study according to OECD 211 with HBED-Fe (CAS no: 1463474 -95 -4) was performed and as expected no effects were observed at 100 mg/L (96.6 mg a.i./L) for any of the tested endpoints.
Algae:
The 72 hour ErC50 value for EDDHMA-Fe with the Selenastrum capricornutum was 71 mg/L and the ErC10 was 2.8 mg/L.
However, due to the chelating properties and coloration of the test solutions, results on algae should be considered with care. The end-point for aquatic plants is likely more representative of actual toxic effects.
Aquatic plants:
In a guideline study on the acute toxicity of EDDHMA-Fe to Lemna minor the EC50-values for inhibition of log biomass growth (EbC50), specific growth rate (ErC50) and log biomass dry weight (EdwC50) were all > 184.2 mg/L, the NOEC was 184.2 mg/L and the LOEC was > 184.2 mg/L.
Microorganisms:
The 3 hours EC10 value for the (read across) test substance EDDHA-FeNa in the Activated Sludge Respiration Inhibition Test was 450 mg/L. The EC50 was greater than 1000 mg/L. Recalculated based on molecular mass correction this would give for EDDHMA-Fe 477 mg/L and > 1060 mg/L for EC10 and EC50 value respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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