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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 221-070-0 | CAS number: 2997-92-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Additional information
For the endpoints short-term toxicity to fish and invertebrates a static and a semi-static study is available. Due to the instablity of the substance and the missing analytical monitoring in the static studies the observed, respectively not observed, effects cannot be equivocally assigned to the substance itself, the transformation products from abiotic processes or a mixture from both. In the semi-static study exposing fish a threshold value of 570 mg/L is calculated. In the static study no effects in all test concentrations are observed. Based on these observations a low acute toxicity of the substance itself and its transformation products is concluded.
In the studies exposing Daphnia magna threshold values of EC50 (48 h) 3.5 mg/L (semi-static) and 4.84 mg/L (static) for aquatic invertebrates are determined. Based on these findings an increased acute toxicity to invertebrates through the transformation products cannot be determined. In the long-term study on toxicity on reproduction of Daphnia no effects on reproduction, parental growth and survival up to a concentration of 2.7 mg/L (TWA) could be observed. Exposure to a TWM concentration of 8.2 mg/L induced significant inhibition of the reproductive capacity of the parental daphnids. This effect is attributable to complete mortality of the parental daphnids at this concentration. Based on the observations a value of EC10 (21d) 3.5 mg/L for reproduction is determined.
For the endpoint toxicity to algae a static study is available only. As analytical monitoring is missing in the study the key component for the observable effect on the inhibition of growth cannot be unequivocally assessed. In the study a threshold value EC50 (72h) of 0.5 mg/L is observed. Additionally, a semi-static long-term study exposing Lemna minor is available indicating a significantly less sensitivity of higher aquatic plants to the substance.
Summarizing the available information it can be concluded that aquatic invertebrates and unicellular algae are significantly more sensitive to the toxic effects of the substance itself and/or its transformation products compared to fish and higher aquatic plants. Additionally, the toxicity of the substance and its transformation products seems to be similar. Therefore, the available information are considered to be sufficient for the assessment and no further assessment of the transformation products is necessary.
Although the trigger component for the effects observed in the static algae study is unequivocally assignable, this value is used in the further assessment and for the classification and labelling of the substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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