Registration Dossier
Registration Dossier
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EC number: 245-950-9 | CAS number: 23949-66-8
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
According to guideline (OECD 111) a half life more than 1 year could be assumed for the test substance at environmental relevant tempeartures.
Key value for chemical safety assessment
Additional information
Hydrolysis as a function of pH was determined according to OECD Guideline n. 111.
Analysis of the test item were performed via LC-MS on a reversed phase column using an external standard. The method was validated with satisfactory results in regard to linearity, accuracy, precision and specificity.
For pH 4,7,9 at 5 day (preliminary) testing at 50°C was performed. During this testing no hydrolysis (less than 10% reduction of the test item) was observed for the pH 4 samples and therefore, with respect to the guideline, a half time greater than 1 year could be assumed for environmental typical temperatures.
For pH 7 and 9 the definitive test was performed. The definitive testing was conducted with a test item concentration of 150 mg/L in buffer solutions of pH 7 and 9 at temperatures of 20, 30 and 50°C, respectively. For pH 7 and 9 samples were taken at test start (h) and at 10 spaced points until test end. Buffer solutions were analysed at test start and test end and there was no analytical interference with the test item. Reaction rate constants and half lives were calculated from the analysed concentrations. The test item showed only slight hydrolysis at the environmental typical temperatures of 20°C and 30°C. At elevated temperature of 50°C moderate elimination of the substance was observed.
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