Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-087-0 | CAS number: 133-06-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
1. Skin irritation (one single dose) study acute dermal irritation (semi-occlusive), rabbit, OECD 404 (1981) = EEC B.4 (1992): mean skin score < 2, primary irritation index of 0.5, classification is not required
2. Eye irritation (one single dose) study acute eye irritation, rabbit, OECD 405 (1987),method B.5 of Regulation (EC) No 440/2008; total score of ocular irritation: 43, captan is classified as irritating with the risk phrase ‘Causes serious eye damage’ (H318)
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 7 August 1991 to 10 August 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1981
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Version / remarks:
- 1984
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- - Physical state: white powder
- Purity: 90.5 %
- Batch number: 4102 L/7
- Date of arrival: 9 July 1991
- Storage conditions: room temperature - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- - three New Zealand white rabbits
- Source: David Percival Ltd., Moston, Sandbach, Cheshire, U.K.
- weight: 2.34 - 2.88 kg
- age: twelve to sixteen weeks old
- free access to mains drinking water and food
- animal room temperature: 20 - 23°C- relative humidity: 60 - 66% - Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- A quantity of 0.5 g of the test material, moistened with 0.5 ml of distilled water, was introduced under a 2.5 cm x 2,5 cm gauze patch and placed In position on the shorn skin.
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- One hour following the removal of the patches, and 1, 24, 48 and 72 hours later, the test sites were examined for evidence of primary irritation and scored according to the scale from Draize J.H. (1959).
- Number of animals:
- three
- Details on study design:
- Captan was applied as a single 0.5 g dermal dose to three New Zealand White rabbits. The test substance, moistened with 0.5 mL distilled water was introduced under a 2.5 x 2.5 cm gauze patch onto shorn skin. After four hours the patch was removed and any residual test material removed. The areawas examined at 1, 24, 48 and 72 hours after the removal of the patch and scored according to Draize (1959).
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 1 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 1 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 1 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 1 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 48 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- animal: #1, #2, #3
- Time point:
- other: 24/72 h
- Score:
- 0.5
- Max. score:
- 8
- Reversibility:
- fully reversible
- Remarks on result:
- probability of mild irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Interpretation of results:
- Category 3 (mild irritant) based on GHS criteria
- Conclusions:
- On the basis of the degree of skin reaction observed (mean skin irritation scores 24 to 72 hours after removal of test substance) and in accordance with the provisions of regulation 1272/2008, Annex I, 3.2, captan is not classified as irritating to rabbit skin.
- Executive summary:
A study was performed to assess the irritancy potential of the test material to the skin of the New Zealand White rabbit. The method used followed that described in the OECD Guidelines for Testing of Chemicals (1981) No. 404 "Acute Dermal Irritation/Corrosion" referenced as EU method B.4 published in the regulation 440/2008.
A single 4-hour, semi-occluded application of the test material to the intact skin of three rabbits produced very slight erythema. All treated skin sites appeared normal 72 hours after treatment.
The test material produced a primary irritation index of 0.5 and was classified as a mild irritant to rabbit skin according to the Draize classification scheme. No corrosive effects were noted.
Reference
The individual scores for erythema/eschar and oedema, are given in Table 7.3.1 -1. Very slight erythema was noted at all treated skin sites one and 24 hours after patch removal and at one treated skin site at the 48-hour observation. All treated skin sites appeared normal 72 hours after treatment.
Table 7.3.1 -1 Dermal irritation responses in rabbits: individual dermal responses
Animal No. |
|
| 52 | 54 | 55 | Mean scores |
Draize grade after | 1 h | O | 0 | 0 | 01 |
|
E | 1 | 1 | 1 | |||
24 h | O | 0 | 0 | 0 | ||
E | 1 | 1 | 1 | |||
48 h | O | 0 | 0 | 0 | ||
E | 0 | 1 | 0 | |||
72 h | O | 0 | 0 | 0 | ||
E | 0 | 0 | 0 | |||
| mean1 | O | 0 | 0 | 0 | |
E | 0.33 | 0.66 | 0.33 | |||
Overall average means1 | O | 0 | ||||
| E | 0.44 |
O = oedema.
E = erythema and eschar formation.
1Mean for individual animals over three time points 24, 48 and 72 hours
for each lesion, calculated as mean score at (24 hours + 48 hours + 72 hours)/3.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 August 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- 1987
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Version / remarks:
- 1984
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- - Physical state: white powder- Purity: 90.5 %
- Batch number: 4102
- Date of arrival: 9 July 1991
- Storage conditions: room temperature - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- - one female New Zealand white rabbit
- Source: David Percival Ltd., Moston, Sandbach, Cheshire, U.K.
- weight: 2.7 kg- age: approximately twelve to sixteen weeks old
- free access to mains drinking water and food
- animal room temperature: 20 - 23°C- humidity: 56% - Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- A single dose of 82 mg (equivalent to 0.1 mL) captan (purity not specified in report; Batch no. 4102) was administered.
- Duration of treatment / exposure:
- 5 hours
- Observation period (in vivo):
- Assessment of ocular damage was made at 1 and 5 hours
- Number of animals or in vitro replicates:
- one female
- Details on study design:
- Material and methods: A single dose of 82 mg (equivalent to 0.1 mL) captan (purity not specified in report; Batch no. 4102) was administered into the elevated lower lid of the right eye of one female New Zealand white rabbit. Immediately after administration of the test material, an assessment of the initial pain reaction was made. Assessment of ocular damage was made at 1 and 5 hours following administration according to Draize (1959).
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Remarks:
- Assessment of ocular damage/irritation of the solid powder (test material) was made approximately 1 and 5 hours following treatment, according OECD 405 (1987), Method B.5 (Commission Directive 84/449/EEC) and Draize J.H. 1959.
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Remarks:
- Assessment of ocular damage/irritation of the solid powder (test material) was made approximately 1 and 5 hours following treatment, according OECD 405 (1987), Method B.5 (Commission Directive 84/449/EEC) and Draize J.H. 1959.
- Irritation parameter:
- conjunctivae score
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Remarks:
- Assessment of ocular damage/irritation of the solid powder (test material) was made approximately 1 and 5 hours following treatment, according OECD 405 (1987), Method B.5 (Commission Directive 84/449/EEC) and Draize J.H. 1959.
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Remarks:
- Assessment of ocular damage/irritation of the solid powder (test material) was made approximately 1 and 5 hours following treatment, according OECD 405 (1987), Method B.5 (Commission Directive 84/449/EEC) and Draize J.H. 1959.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Remarks:
- Assessment of ocular damage/irritation of the solid powder (test material) was made approximately 1 and 5 hours following treatment, according OECD 405 (1987), Method B.5 (Commission Directive 84/449/EEC) and Draize J.H. 1959.
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- animal #1
- Time point:
- other: 5 h
- Score:
- 43
- Max. score:
- 80
- Reversibility:
- not reversible
- Remarks on result:
- probability of moderate irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- 0
- Max. score:
- 80
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 5 h
- Score:
- 20
- Max. score:
- 80
- Reversibility:
- not reversible
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- 5
- Max. score:
- 10
- Reversibility:
- not reversible
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 5 h
- Score:
- 5
- Max. score:
- 10
- Reversibility:
- not reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- 16
- Max. score:
- 20
- Reversibility:
- not reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 5 h
- Score:
- 18
- Max. score:
- 20
- Reversibility:
- not reversible
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- There was no evidence of recovery during the observation period following administration of the test substance since the study was terminated after 5 hours. In accordance the provisions of regulation 1272/2008, Annex I, 3.3 captan is classified as eye damaging category 1 with the hazard statement H318: Causes serious eye damage
- Executive summary:
A study was performed to assess the irritancy potential of captan to the eye of the New Zealand White rabbit. The method used followed that described in the OECD Guidelines for Testing of Chemicals (1987) No. 405 "Acute Eye Irritation/Corrosion" referenced as EEC method B.5 published in the regulation 440/2008. A single application of the test material to the non-irrigated eye of one rabbit produced areas of diffuse corneal opacity, iridial inflamm ation and severe conjunctival irritation. Other adverse ocular reactions noted were a dulling of the normal lustre of the corneal surface and haemorrhage of the nictitating and conjunctival membranes. The animal was killed for humane reasons immediately after the five hour observation in accordance with current U.K. Home Office guidelines. The test material produced a maximum total score of 43. There was no evidence of recovery during the observation period following administration of the test substance since the study was terminated after 5 hours. In accordance the provisions of regulation 1272/2008, Annex I, 3.3 captan is classified as eye damaging category 1 with the hazard statement H318: Causes serious eye damage
Reference
A dulling of the normal lustre of the corneal surface was noted in the treated eye one hour after treatment with areas of diffuse corneal opacity at the 5 hour observation. Iridial Inflammation was noted in the treated eye one and 5 hours after treatment. Severe conjunctival Irritation was noted in the treated eye one and 5 hours after treatment. Haemorrhage of the nictitating and conjunctival membranes was also noted in the treated eye at the 5 hour observation.
Table 7.3.2-1 Ocular irritation in the rabbit
Rabbit: female, number #1 |
IPR 2 |
|
|
Draize grade: |
|||
Time after Treatment |
1 h |
5 h |
|
Tissue |
Signs |
|
|
Cornea |
E = Degree of Opacity |
d |
1 |
|
F = Area of Opacity |
4 |
4 |
Score (E x F) x 5 |
0 |
20 |
|
Iris |
D = Iritis |
1 |
1 |
Score (D x 5) |
5 |
5 |
|
Conjunctiva |
A = Redness |
2 |
2H |
|
B = Chemosis |
3 |
4 |
|
C = Discharge |
3 |
3 |
Score (A + B + C) x 2 |
16 |
18 |
|
Total Score |
21 |
43 |
IPR: Initial Pain Reaction
d: dulling of the normal lustre of the corneal surface
H: haemorrhage of the nictitating and conjunctival membranes
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The study according to OECD 404 on three rabbits produced very slight erythema. All treated skin sites appeared normal 72 hours after treatment. The test material produced a primary irritation index of 0.5 and was classified as a mild irritant to rabbit skin according to the Draize classification scheme. No corrosive effects were noted.
The study according to OECD 405 to the non-irrigated eye of one rabbit produced areas of diffuse corneal opacity, iridial inflammation and severe conjunctival irritation. Other adverse ocular reactions noted were a dulling of the normal lustre of the corneal surface and haemorrhage of the nictitating and conjunctival membranes. The test material produced a maximum total score of 43. There was no evidence of recovery during the observation period following administration of the test substance since the study was terminated after 5 hours. In accordance with regulation 1272/2008, Annex I, 3.3 captan is classified as eye damaging category 1 with the hazard statement H318: Causes serious eye damage
Effects on skin irritation/corrosion: slightly irritating
Effects on eye irritation: highly irritating
Justification for classification or non-classification
In a study on skin irritation the test material caused reversible slight erythema with a primary irritation index of 0.5 (mild irritant) not leading to classification according to EU regulation 1272/2008.
In eye irritation study there were severe effects on the eyes and no evidence of recovery during the observation period following administration of the test substance. In accordance with regulation 1272/2008, Annex I, 3.3 captan is classified as eye damaging category 1 with the hazard statement H318: Causes serious eye damage.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)