Registration Dossier
Registration Dossier
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EC number: 202-424-3 | CAS number: 95-49-8
Toxicity to reproduction
Administrative data
- Endpoint:
- toxicity to reproduction
- Remarks:
- other: effects on spermatogenesis
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: speramtogenesis was examined in an acute toxicity study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
- Principles of method if other than guideline:
- 3 males/dose, pathological examination of the survivors
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-chlorotoluene
- EC Number:
- 202-424-3
- EC Name:
- 2-chlorotoluene
- Cas Number:
- 95-49-8
- Molecular formula:
- C7H7Cl
- IUPAC Name:
- 1-chloro-2-methylbenzene
- Details on test material:
- purity: no data, diluted in an inert dispersing medium
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Alderley Park
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on mating procedure:
- not applicable -
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- Exposure period: single administration
Duration of test: 7 days - Frequency of treatment:
- single treatment
- Details on study schedule:
- survivors were observed for 7 days when they were killed for pathological examination
Doses / concentrations
- Remarks:
- Doses / Concentrations:
10800, 5420, 2700 mg/kg bw
Basis:
nominal conc.
- No. of animals per sex per dose:
- 3 animals
- Control animals:
- not specified
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Dose descriptor:
- NOAEL
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified Generation not specified (migrated information)
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
Mortality: high dose: 3/3, middle dose: 2/3, low dose: 0/3; microscopically all the survivors showed a reduction in spermatogenesis (no further data).
Applicant's summary and conclusion
- Executive summary:
Groups of 3 male rats were given one dose of 10.8, 5.42 or 2.7 g/kg bw by stomach tube and the survivors observed for 7 days when they were killed for pathological examination. Microscopically all the males showed a reduction in spermatogenesis.
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