3-aminomethyl-3,5,5-trimethylcyclohexylamine

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2002-08-02 to 2002-08-12

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Guideline study

Qualifier:

according to guideline

Guideline:

EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)

Version / remarks:

(1981)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 111 (Hydrolysis as a Function of pH)

Version / remarks:

(1992)

Deviations:

no

GLP compliance:

yes

Radiolabelling:

no

Analytical monitoring:

yes

Details on sampling:

At test start (= 0 hours), 2.4 hours, 5 days

Buffers:

pH 4: citric acid - hydrochloric acid
pH 7: potassium dihydrogen phosphate - disodium hydrogen phosphate
pH 9: boric acid -potassium chloride - sodium hydroxide

Details on test conditions:

Only preliminary test performed

Duration:

5 d

pH:

4

Temp.:

50

Initial conc. measured:

1 010 mg/L

Duration:

5 d

pH:

7

Temp.:

50

Initial conc. measured:

1 062 mg/L

Duration:

5 d

pH:

9

Temp.:

50

Initial conc. measured:

1 013 mg/L

Number of replicates:

2

Positive controls:

not specified

Negative controls:

not specified

Statistical methods:

average of two determinations

Preliminary study:

Less than 10 % degradation was observed after 5 days at 50 degree C and pH 4, 7, and 9.
Observed degree of hydrolysis (determined twice):
pH 4: 2.58 %, 3.68 %
pH 7: 1.36 %, 2.59 %
pH 9: not detectable (-3.16 %, -1.18 %)

Test performance:

Main test: not required

Transformation products:

not measured

% Recovery:

< 90

Temp.:

50 °C

Duration:

5 d

pH:

4

Temp.:

25 °C

DT50:

> 1 yr

pH:

7

Temp.:

25 °C

DT50:

> 1 yr

pH:

9

Temp.:

25 °C

DT50:

> 1 yr

Details on results:

at 50 °C: Degradation (in %): < 10 after 5day(s)

Validity criteria fulfilled:

not specified

Conclusions:

Isophorone diamine does not show a significant sensitivity towards hydrolysis. In the preliminary test, less than 10% of the test substance was observed to hydrolyse at 50 °C at pH 4,7 and 9 after 5 days. There was no need to perform a main test.

Executive summary:

The hydrolysis as a function of pH of the test substance was determined by Infracor (2002) according to OECD TG 111 (1981) and EU method C.7 (1992). In the preliminary test, less than 10% of the test substance was observed to hydrolyse at 50 °C at pH 4,7 and 9 after 5 days. Thus additional testing (main test) is not required.

 

The study was assessed as "reliable without restrictions".

Description of key information

Isophorone diamine does not show a significant sensitivity towards hydrolysis. In the preliminary test, less than 10% of the test substance was observed to hydrolyse at 50 °C at pH 4,7 and 9 after 5 days. There was no need to perform a main test.