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EC number: 204-424-9 | CAS number: 120-78-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Nov 2015 - Jan 2016
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Remarks:
- via HPLC-MS-MS
- Details on sampling:
- Sampling schedule:
Control : on day 0, 9 and 19 in the freshly prepared media; on day 2, 12 and 21 in the old media
Test concentration : on day 0, 9 and 19 in the freshly prepared media; on day 2, 12 and 21 in the old media - Vehicle:
- no
- Details on test solutions:
- Ensured by renewal of test media three times per week and verified by chemical analysis (HPLC-MS-MS) according to the sampling scheme described below.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Daphnia magna STRAUS, parthenogenetic females
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 21 d
- Hardness:
- The hardness of the dilution water ranged from 14.0 °dH to 16.0 °dH
(= 250 – 286 mg/L CaCO3) during the test. - Test temperature:
- 20 +/- 2 °C
- pH:
- 7.6 - 7.8
- Dissolved oxygen:
- > 3 mg/L throughout exposure period
- Nominal and measured concentrations:
- 10 mg/L (nominal)
- Details on test conditions:
- A 16 : 8 hour light-dark photoperiod (light intensity: < 20 μE x m-2 x s-1) was applied. The culture water (so-called 'M4 medium') was partly renewed once a week.
- Reference substance (positive control):
- no
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks on result:
- other: equal an analytical value of 0.1 μg/L (limit of quantitation).
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- > 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks on result:
- other: equal an analytical value of 0.1 μg/L (limit of quantitation).
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: equal an analytical value of 0.1 μg/L (limit of quantitation).
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- > 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: equal an analytical value of 0.1 μg/L (limit of quantitation).
- Details on results:
- The criterion of adverse effects used in this study was the item-induced inhibitory effect on the parthenogenetic reproduction rate and the mobility behaviour/mortality rate of parent Daphnia, all effects being assessed at least three times a week.
- Validity criteria fulfilled:
- yes
- Conclusions:
- No toxic effects of Rubator MBTS against Daphnia were observed at a limit test concentration of 10 mg/L (nominal) over 21 days, which equals to an analytical value of 0.1 μg/L (limit of quantitation).
- Executive summary:
Long-term toxicity on invertebrates were investigated according to OECD 211 over 21 days under semi static conditions in a daphnia reproduction test. Analysis was performed via HPLC-MS-MS. As a result, Rubator MBTS showed no toxic effect in a limit test with a nominal concentration of 10 mg/L which equal an analytical value of 0.1 µg/L which was the limit of quantification (Currenta, 2016). Therefore a 21d-NOEC of >= 10 mg/L (reproduction and mortality) and 21d-LOEC of > 10 mg/L (reproduction and mortality) could be determined.
Reference
Description of key information
No toxic effects of Rubator MBTS against Daphnia were observed at a limit test concentration of 10 mg/L (nominal) over 21 days, which equals to an analytical value of 0.1 μg/L (limit of quantitation).
Key value for chemical safety assessment
Additional information
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