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Diss Factsheets
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EC number: 204-424-9 | CAS number: 120-78-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
In conclusion, the test substance MBTS showed a practically non-irritating potential to rabbit skin (Monsanto Co. 1973). This negative finding was confirmed in a Repeated Insult Patch Test with human volunteers (Monsanto Co. 1982). A low eye irritation potential of MBTS was revealed in an eye irritation study with New Zealand albino rabbits (Monsanto Co 1973).
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited but acceptable documented study report which meets basic scientific principles
- Principles of method if other than guideline:
- In vivo skin irritation study
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: intact and abraded skin
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 7 days
- Number of animals:
- 6
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24, 72 h
- Score:
- 0
- Max. score:
- 8
- Reversibility:
- other: no effects observed
- Remarks on result:
- other: no effects
- Interpretation of results:
- GHS criteria not met
Reference
No skin irritating effects observed in any of the treated animals.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited but acceptable documented study report which meets basic scientific principles
- Principles of method if other than guideline:
- In vivo eye irritation study
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 6
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0.6
- Max. score:
- 110
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: immediate: slight discomfort, 10 min: slight erythema, moderate discharge
- Interpretation of results:
- GHS criteria not met
Reference
Immediate: slight discomfort
10 minutes: slight erythema, moderate discharge
1 hour: slight erythema, moderate discharge
24 hours: slight erythema (mean score 24 h: 2/110)
48 hours: all scored zero
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin
The skin irritation potential of the test substance MBTS was evaluated in a skin irritation study with six New Zealand Albino rabbits (Monsanto Co.1973). The finely ground test substance (0.5 mg) moistened with water was applied under semi-occlusive dressings to clipped intact and abraded skin of 6 New Zealand albino rabbits for 24 hours. A 7 day observation period followed the test substance application. Skin response were scored in accordance with the Federal Hazardous substances Act (F.H.S.A.), 21 CFR, § 191.12 (1964).The test substance MBTS was practically non-irritating to rabbit skin (mean irritation score intact and abraded skin 24 and 72 h average: 0).
The negative finding in animals was confirmed in a Repeated Insult Patch test (modified Shelanski 4 x 4 Method) with human volunteers (Monsanto Co. 1982). No indication of skin irritation (0/53 volunteers) was observed after repeated dermal application of the test substance (70% in petrolatum).
Eye
The eye irritating potential of the test substance MBTS was evaluated in an eye irritation study with six New Zealand albino rabbits (Monsanto Co. 1973). The finely ground test substance (100 mg) was placed into eyes of six rabbits. A 7-day observation period followed the application of the test substance. Eye responses were scored in accordance with the Federal Hazardous substances Act (F.H.S.A.), 21 CFR, § 191.12 (1964).
The test substance was slightly irritating to the rabbit eye (mean irritation score 24, 48, and 72 hours: 0.6/110.0). Effects on the conjunctivae were noted in all animals at 24 hours (mean score 24 h: 2/110) but were reversible within 48 hours. The test substance was not classified as eye irritating.
Justification for classification or non-classification
According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification for skin and eye irritation is not justified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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