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Diss Factsheets
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EC number: 204-424-9 | CAS number: 120-78-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Epidemiological data
Administrative data
- Endpoint:
- epidemiological data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable, well-documented publication which meets basic scientific principles
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Mortalities of workers at the nitro plant with exposure to 2-mercaptobenzothiazole
- Author:
- Collins, J., J.; et al.
- Year:
- 1 999
- Bibliographic source:
- Occup. Environ. Med. 56, 667-671
- Reference Type:
- other: microfiche
- Title:
- An update of the 2-mercaptobenzothiazole study at the nitro plant, study 9504, January 1996
- Author:
- Monsanto Co.
- Year:
- 1 996
- Bibliographic source:
- NTIS/OTS0572929
Materials and methods
- Study type:
- cohort study (retrospective)
- Endpoint addressed:
- carcinogenicity
- Principles of method if other than guideline:
- other: cohort mortality study
- GLP compliance:
- no
Test material
- Reference substance name:
- Benzothiazole-2-thiol
- EC Number:
- 205-736-8
- EC Name:
- Benzothiazole-2-thiol
- Cas Number:
- 149-30-4
- Molecular formula:
- C7H5NS2
- IUPAC Name:
- 1,3-benzothiazole-2-thiol
- Details on test material:
- MBT
Constituent 1
Method
- Details on study design:
- cohort mortality study, examination of mortality of MBT exposed worker
- Exposure assessment:
- estimated
Results and discussion
- Results:
- Exposure to MBT does not seem to increase the risk of most cancer including cancers of the lung and prostate.
The confounding effect of PAB makes it impossible to evaluate MBT induced risk of bladder cancer in this population at this time. - Confounding factors:
- exposure to 4-aminobiphenyl (PAB)
Any other information on results incl. tables
MBT workers have expected rates of lung and prostate cancer. There was an excess of bladder cancer among MBT worker who had definite exposure to PAB and MBT workers with potential exposure to PAB. However, there were no deaths from bladder cancer among workers with no exposure to PAB.
The authors concluded that the potential confounding of exposure to an unknown portion of PAB in the MBT workers makes it impossible to evaluate risk of bladder cancer in this population at this time. However, exposure to MBT doses not seem to increase the risk of most cancers including cancers of the lung and prostate.
Applicant's summary and conclusion
- Conclusions:
- MBT workers have expected rates of lung and prostate cancer. There was an excess of bladder cancer among MBT worker who had definite exposure to PAB and MBT workers with potential exposure to PAB. However, there were no deaths from bladder cancer among workers with no exposure to PAB.
The authors concluded that the potential confounding of exposure to an unknown portion of PAB in the MBT workers makes it impossible to evaluate risk of bladder cancer in this population at this time. However, exposure to MBT doses not seem to increase the risk of most cancers including cancers of the lung and prostate. - Executive summary:
In a follow up study, the mortalities of workers at the Nitro plant (West Virginia) with exposure to 2-mercaptobenzothiazole were evaluated (Collins 1999). In this study the mortalities of 1059 full time white male production workers employed at the plant from 1955 to 1977 were analyses. A detailed exposure assessment was done on the 600 workers with exposure to MBT. Nine years of additional follow up to the previous study (Strauss 1993) were added. In the follow-up study the standardised mortality ratios of the production workers for all causes of death and all cancers was at expected levels, which was different from the findings of the original study (Strauss 1993). For the entire follow up period lung cancer, prostate cancer, and the other cancer sites examined were at expected levels. Among the cancers, only rates of bladder cancer were greater than expected for the entire follow up period. The standardised mortality ratios for total cancer of workers exposed to MBT and potential exposure to PAB were similar to the entire study group and to the local population. Rates for lung cancer and prostate cancer were at expected levels. The standardised mortality ratio for bladder cancer was greater than expected when compared with the external reference group. The number of total cancers was greater than expected for MBT workers with one or more jobs with exposure to PAB. The number of lung cancers and bladder cancers for this group of workers were greater than expected. The MBT workers without a job definite exposure to PAB during their careers had an observed total cancer rate which was lower than expected. Observed deaths from bladder cancer, however, were greater than expected in this group based on five deaths. The five workers who died of bladder cancer held jobs with plant-wide responsibilities. These five workers had job titles of maintenance worker, yard labourer, or general production worker and thus the authors suggested that a possible risk of exposure to PAB. Workers with no potential exposure to PAB, or those workers hired after 1955, have a lower observed than expected risk of total cancer and there were no deaths from bladder cancer. The authors concluded that MBT workers had bladder cancer rates which were greater than expected, but an unknown portion of these workers had exposure to PAB. The potential confounding exposure to PAB, a potent bladder carcinogen, in an unknown portion of the MBT workers makes it impossible to evaluate risk of bladder cancer in this population. Although the lack of bladder cancers among workers hired after PAB manufacture ended would argue against a relation with exposure to MBT, the number of expected deaths in this group of workers is too small to be conclusive.
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