Talc (Mg3H2(SiO3)4)

Long-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

long-term toxicity to aquatic invertebrates

Data waiving:

other justification

Justification for data waiving:

other:

Reference 2

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

QSAR prediction:(Q)SAR calculated endpoint

Qualifier:

according to guideline

Guideline:

other: QSAR

Principles of method if other than guideline:

EPI Suite v 4.0/ECOSARv1.00

GLP compliance:

no

Remarks:

not applicable to QSAR models

Analytical monitoring:

not required

Vehicle:

not specified

Test organisms (species):

other: Daphnid species

Details on test organisms:

no further information

Test type:

other: QSAR model

Water media type:

freshwater

Limit test:

no

Total exposure duration:

30 d

Hardness:

not applicable. QSAR model

Test temperature:

not applicable. QSAR model

pH:

not applicable. QSAR model

Dissolved oxygen:

not applicable. QSAR model

Salinity:

not applicable. QSAR model

Details on test conditions:

Chem Name : Talc (Mg3H2(SiO3)4)
Molecular Wt: 379.27
Henry's LC : 5.54e-029 atm-m3/mole (calc VP/Wsol)
Vapor Press : 1.11e-022 mm Hg (Mpbpwin program)
Liquid VP : 1.15e-019 mm Hg (super-cooled)
Melting Pt : 330 deg C (Mpbpwin program)
Log Kow : -9.4 (Kowwin program)
Soil Koc : 31.82 (KOCWIN MCI method)

Reference substance (positive control):

no

Duration:

30 d

Dose descriptor:

NOEC

Effect conc.:

1 459.798 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: (Q)SAR prediction

Remarks on result:

other: non-toxic as determined by (Q)SAR

Details on results:

Daphnid, 30-day,NOEC for freshwater species cited as ChV (chronic value) =1459.798 mg/L (ppm).A NOEC value of 1459.798 mg/L has been calculated for the effects of the test substance on the mortality of the Daphnid. This result signifies that the test substance is not expected to be toxic. A reliable NOEC value of 1459.798 mg/L has been calculated for the effects of the test substance towards Daphnid.

Reported statistics and error estimates:

 Daphnid , 48-hr LC50 =   36812.359mg/L (ppm)

Overview of QSARs estimations on long-term aquatic toxicity of   Talc (Mg3H2(SiO3)4) to Daphnid     

Method	Results	Remarks	Reference
QSAR estimate	Daphnid, 30-day, ChV (chronic value) = 1459.798 mg/L (ppm)   Daphnid , 48-hr LC50 =  36812.359 mg/L (ppm)	Reliable with restrictions, QSAR estimated data	ECOSAR Program (v1.00)

ECOSAR QSAR model predicts that NOEC for fresh water species Daphnid cited as ChV (chronic value) would to be  1459.798 mg/l. This result signifies that the test substance is not expected to be toxic.

Daphnid, 30-day, ChV (chronic value) =   1459.798mg/L (ppm)  

Daphnid , 48-hr LC50 =   36812.359mg/L (ppm)

Validity criteria fulfilled:

yes

Remarks:

US EPA accepted QSAR method for chemicals properties assessment.

Conclusions:

Daphnid, 30-day,NOEC for freshwater species cited as ChV (chronic value) = 1459.798 mg/L (ppm).A NOEC value of 1459.798 mg/L has been calculated for the effects of the test substance on the mortality of the Daphnid. This result signifies that the test substance is not expected to be toxic. A reliable NOEC value of 1459.798 mg/L has been calculated for the effects of the test substance towards Daphnid.

Executive summary:

ECOSAR QSAR model predicts that NOEC for fresh water species Daphnid cited as ChV (chronic value) would to be 1459.798 mg/l. This result signifies that the test substance is not expected to be toxic.

Description of key information

The substance is inorganic almost insoluble powder in aqueous solution and Talc (Mg3H2(SiO3)4) is not expected to be harmful to aquatic life. The material is non-biodegradable, retaining its structure in the environment. At normal water course pH’s this material is stable. It does not hydrolyze in water .The majority of the applications for which this substance is used will not result in the material being released to water courses directly. If low concentrations do get through the water treatment process and enter the water course, the fact that the material does not biodegrade, is stable, not hydrolyses suggest that transfer across biological membranes is unlikely. Short term aquatic toxicity tests reported in the literature (LC50 Brachydanio rerio (Zebra fish) >100000 mg/L/24 hr; for Talc) show this substance is not toxic to aquatic life. On this basis the need for long term aquatic testing is waived. On this basis, the need for further testing for this end point has been waived and being unnecessary and scientifically unjustified.

 

ECOSAR QSAR model predicts that NOEC for fresh water species Daphnid cited as ChV (chronic value) would to be 1459.798 mg/l. This result signifies that the test substance is not expected to be toxic.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

1 459.798 mg/L

Marine water invertebrates

Marine water invertebrates

Effect concentration:

145.98 mg/L

Additional information

The available data for marine water Daphnid are limited and to obtaine the value for PNECs for saltwaters is taken account a assesment factor 10 to extrapolate to LC50 following the “Guidance on Information Requirement and Chemical Safety Assessment R.10: Characterisation of dose [concentration]- response for environment”and “Table R.10-5 Assessment factors proposed for deriving PNEC water for saltwater for different data sets”, to account for the possibility that greater taxonomic diversity in the marine environment makes it likely that some marine taxa may be more sensitive than the most sensitive freshwater taxa.