Diphenylacetonitrile

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

experimental data of read across substances

Justification for type of information:

Data for the target chemical is summarized based on the structurally similar read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

WoE report is based on two hydrolysis studies as-
2. and 3.

GLP compliance:

not specified

Radiolabelling:

not specified

Analytical monitoring:

yes

Remarks:

2. Yes and 3. No data available

Temp.:

25 °C

Initial conc. measured:

18.4 mg/L

Remarks:

2. The study was performed at pH 4, 7 and 9, respectively.

Remarks:

3. The study was performed at pH 5, 7 and 9, respectively.

Positive controls:

not specified

Negative controls:

not specified

Transformation products:

not specified

Details on hydrolysis and appearance of transformation product(s):

2. The degradation product of test chemical was formed.
3. No data available

pH:

4

Temp.:

25 °C

DT50:

75 d

Type:

(pseudo-)first order (= half-life)

Remarks on result:

other: 2. Other details not known

pH:

7

Temp.:

25 °C

DT50:

42 d

Type:

(pseudo-)first order (= half-life)

Remarks on result:

other: 2. Other details not known

pH:

5

DT50:

44 d

Remarks on result:

other: 3. Other details not known

Details on results:

2. Test chemical was degraded faster than at pH 4 and 7. At pH 9 the reaction did not show pseudo-first order behaviour and no half live could be derived for different temperatures according to Arrhenius equation.
The half-life period of test chemical was determined to be 75 and 42 days at pH 4.0 & 7, respectively and thus, test chemical was reported to be hydrolytically stable.
3. The half-life period of test chemical was determined to be 44 days at pH 5.0 and test chemical was reported to be hydrolytically stable at pH 7 and 9, respectively.

2.

Table:Half-lives of test chemical (h).

Temperature (°C)	pH
	4	7	9
50	80.3	57.4	5.4
70	18.7	14.9	1.7
85	2.4	2.2	1.0

 

Arrhenius-Factors for the temperature dependence can be derived from the above mentioned data and were in the range of 1.42 - 3.93 (average 2.46) per 10 °C of temperature increase.

3. No data available

Validity criteria fulfilled:

not specified

Conclusions:

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 42 days to 75 days at pH 4, 5 and 7, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is considered to be hydrolytically stable.

Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical. The studies are as mentioned below:

The half-life of the test chemical was determined at different pH range. The study was performed according to EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH) (Directive 92/69/EEC, C.7). Test chemical concentration used for the study was 18.4 mg/l. At the start, each assay was treated with argon (according to guideline) to ensure anaerobic conditions at that time. All test vessels were incubated in the dark. Analytical method involve the use of HPLC.The study was performed at pH of 4, 7 and 9 and temperature of 25°C, respectively. The half-life period of test chemical was determined to be 75 and 42days at pH 4.0 & 7 and temperature of 25°C. Thus, based on this, test chemical is considered to be hydrolytically stable.

In an another study, the half-life of the test chemical was determined at different pH range. The study was performed at pH of 5, 7 and 9, respectively. The half-life period of test chemical was determined to be 44 days at pH 5.0 and test chemical was reported to be hydrolytically stable at pH 7 and 9, respectively.

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 42 days to 75 days at pH 4, 5 and 7, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is considered to be hydrolytically stable.

Description of key information

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 42 days to 75 days at pH 4, 5 and 7, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is considered to be hydrolytically stable.

Additional information

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical. The studies are as mentioned below:

 

The half-life of the test chemical was determined at different pH range. The study was performed according to EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH) (Directive 92/69/EEC, C.7). Test chemical concentration used for the study was 18.4 mg/l. At the start, each assay was treated with argon (according to guideline) to ensure anaerobic conditions at that time. All test vessels were incubated in the dark. Analytical method involve the use of HPLC. The study was performed at pH of 4, 7 and 9 and temperature of 25°C, respectively. The half-life period of test chemical was determined to be 75 and 42days at pH 4.0 & 7 and temperature of 25°C. Thus, based on this, test chemical is considered to be hydrolytically stable.

 

In an another study, the half-life of the test chemical was determined at different pH range. The study was performed at pH of 5, 7 and 9, respectively. The half-life period of test chemical was determined to be 44 days at pH 5.0 and test chemical was reported to be hydrolytically stable at pH 7 and 9, respectively.

 

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 42 days to 75 days at pH 4, 5 and 7, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is considered to be hydrolytically stable.