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EC number: 201-662-5 | CAS number: 86-29-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data of read across substances
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on two hydrolysis studies as-
2. and 3. - GLP compliance:
- not specified
- Radiolabelling:
- not specified
- Analytical monitoring:
- yes
- Remarks:
- 2. Yes and 3. No data available
- Temp.:
- 25 °C
- Initial conc. measured:
- 18.4 mg/L
- Remarks:
- 2. The study was performed at pH 4, 7 and 9, respectively.
- Remarks:
- 3. The study was performed at pH 5, 7 and 9, respectively.
- Positive controls:
- not specified
- Negative controls:
- not specified
- Transformation products:
- not specified
- Details on hydrolysis and appearance of transformation product(s):
- 2. The degradation product of test chemical was formed.
3. No data available - pH:
- 4
- Temp.:
- 25 °C
- DT50:
- 75 d
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: 2. Other details not known
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- 42 d
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: 2. Other details not known
- pH:
- 5
- DT50:
- 44 d
- Remarks on result:
- other: 3. Other details not known
- Details on results:
- 2. Test chemical was degraded faster than at pH 4 and 7. At pH 9 the reaction did not show pseudo-first order behaviour and no half live could be derived for different temperatures according to Arrhenius equation.
The half-life period of test chemical was determined to be 75 and 42 days at pH 4.0 & 7, respectively and thus, test chemical was reported to be hydrolytically stable.
3. The half-life period of test chemical was determined to be 44 days at pH 5.0 and test chemical was reported to be hydrolytically stable at pH 7 and 9, respectively.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 42 days to 75 days at pH 4, 5 and 7, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is considered to be hydrolytically stable.
- Executive summary:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical. The studies are as mentioned below:
The half-life of the test chemical was determined at different pH range. The study was performed according to EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH) (Directive 92/69/EEC, C.7). Test chemical concentration used for the study was 18.4 mg/l. At the start, each assay was treated with argon (according to guideline) to ensure anaerobic conditions at that time. All test vessels were incubated in the dark. Analytical method involve the use of HPLC.The study was performed at pH of 4, 7 and 9 and temperature of 25°C, respectively. The half-life period of test chemical was determined to be 75 and 42days at pH 4.0 & 7 and temperature of 25°C. Thus, based on this, test chemical is considered to be hydrolytically stable.
In an another study, the half-life of the test chemical was determined at different pH range. The study was performed at pH of 5, 7 and 9, respectively. The half-life period of test chemical was determined to be 44 days at pH 5.0 and test chemical was reported to be hydrolytically stable at pH 7 and 9, respectively.
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 42 days to 75 days at pH 4, 5 and 7, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is considered to be hydrolytically stable.
Reference
2.
Table:Half-lives of test chemical (h).
Temperature (°C) |
pH |
||
4 |
7 |
9 |
|
50 |
80.3 |
57.4 |
5.4 |
70 |
18.7 |
14.9 |
1.7 |
85 |
2.4 |
2.2 |
1.0 |
Arrhenius-Factors for the temperature dependence can be derived from the above mentioned data and were in the range of 1.42 - 3.93 (average 2.46) per 10 °C of temperature increase.
3. No data available
Description of key information
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 42 days to 75 days at pH 4, 5 and 7, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is considered to be hydrolytically stable.
Key value for chemical safety assessment
Additional information
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical. The studies are as mentioned below:
The half-life of the test chemical was determined at different pH range. The study was performed according to EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH) (Directive 92/69/EEC, C.7). Test chemical concentration used for the study was 18.4 mg/l. At the start, each assay was treated with argon (according to guideline) to ensure anaerobic conditions at that time. All test vessels were incubated in the dark. Analytical method involve the use of HPLC. The study was performed at pH of 4, 7 and 9 and temperature of 25°C, respectively. The half-life period of test chemical was determined to be 75 and 42days at pH 4.0 & 7 and temperature of 25°C. Thus, based on this, test chemical is considered to be hydrolytically stable.
In an another study, the half-life of the test chemical was determined at different pH range. The study was performed at pH of 5, 7 and 9, respectively. The half-life period of test chemical was determined to be 44 days at pH 5.0 and test chemical was reported to be hydrolytically stable at pH 7 and 9, respectively.
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 42 days to 75 days at pH 4, 5 and 7, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is considered to be hydrolytically stable.
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