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EC number: 201-662-5 | CAS number: 86-29-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Weight of evidence approach based on the available data of the read-across chemicals.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- read-across source
Reference
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from a secondary literature
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Principles of method if other than guideline:
- Equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- not specified
- Type of study:
- other: maximization test
- Justification for non-LLNA method:
- not specified.
- Species:
- human
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No Data Available
- Positive control results:
- No Data Available
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- 2% in petrolatum
- No. with + reactions:
- 0
- Total no. in group:
- 27
- Clinical observations:
- No effects were observed.
- Remarks on result:
- no indication of skin sensitisation
- Interpretation of results:
- other: The test chemical did not show any skin sensitization potential, since no positive reactions were observed at tested dose levels.
- Conclusions:
- Based on all the observations and results, it was concluded that the test chemical was is not likely to be sensitizing, when tested in 27 human volunteers.
- Executive summary:
The skin sensitization study of the test chemical was performed in 27 volunteers to determine its sensitization potential by maximization test. The study was conducted by using 2% of the test chemical in petrolatum, which was used as vehicle and was applied on 27 volunteers and observations were made. All the 27 human volunteers did not show any signs of irritation or sensitization. Thus, from the above observations, the test chemical did not show any skin sensitization potential, since no positive reactions were observed at tested dose levels. Based on all the observations and results, it was concluded that the test chemical was is not likely to be sensitizing, when tested in 27 human volunteers.
- Reason / purpose for cross-reference:
- read-across source
Reference
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from IUCLID dataset
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Principles of method if other than guideline:
- Equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- not specified
- Type of study:
- not specified
- Justification for non-LLNA method:
- not specified.
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No Data Available
- Positive control results:
- No Data Available
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- 2% in petrolatum
- No. with + reactions:
- 0
- Total no. in group:
- 35
- Clinical observations:
- No effects
- Remarks on result:
- other: Reading: 1st reading. Group: test group. Dose level: 2% in petrolatum. No with. + reactions: 0.0. Total no. in groups: 35.0. Clinical observations: skin evaluation.
- Interpretation of results:
- other: The test chemical does not have a sensitization potential as there were no signs of irritation or sensitization in the tested animals.
- Conclusions:
- Based on all the observations and results, it was concluded that the test chemical is not likely to cause any sensitization in guinea pigs when tested in 35 animals.
- Executive summary:
The skin sensitization study of the test chemical was performed in 35 guinea pigs to determine its sensitization potential. In this study, 2% of test chemical was in petrolatum, which was used as a vehicle was applied on guinea pigs and observations were made. After application of the test chemical, it was observed that no effect of the test chemical was observed in all the 35 animals that were tested. There was no signs of irritation or sensitization which was caused by the test chemical. Thus, based on all the observations and result, it was concluded that the test chemical is not likely to cause any sensitization in guinea pigs when tested in 35 animals.
Data source
Reference
- Reference Type:
- other: Secondary literature
- Title:
- Assessment of skin sensitization potential of the test chemical.
- Author:
- Sustainability Support Services (Europe) AB
- Year:
- 2 019
- Bibliographic source:
- SSS_SkinSens_2019_86293
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Principles of method if other than guideline:
- Equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- not specified
- Type of study:
- not specified
- Justification for non-LLNA method:
- not specified.
Test material
- Reference substance name:
- Diphenylacetonitrile
- EC Number:
- 201-662-5
- EC Name:
- Diphenylacetonitrile
- Cas Number:
- 86-29-3
- Molecular formula:
- C14H11N
- IUPAC Name:
- 2,2-diphenylacetonitrile
- Test material form:
- not specified
- Details on test material:
- Name: Diphenylacetonitrile
Molecular Weight: 193.248 g/mol
Molecular Formula: C14-H11-N
SMILES: C(c1ccccc1)(c1ccccc1)C#N
Constituent 1
In vivo test system
Test animals
- Species:
- other: Study 2: Human; Study 3: Guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No Data Available
Results and discussion
- Positive control results:
- No Data Available
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- 2% in petrolatum (Study 2)
- No. with + reactions:
- 0
- Total no. in group:
- 27
- Clinical observations:
- No effects were observed. (Study 2)
- Remarks on result:
- no indication of skin sensitisation
- Remarks:
- Study 2
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- 2% in petrolatum (Study 3)
- No. with + reactions:
- 0
- Total no. in group:
- 35
- Clinical observations:
- No effects (Study 3)
- Remarks on result:
- other: Reading: 1st reading. Group: test group. Dose level: 2% in petrolatum. No with. + reactions: 0.0. Total no. in groups: 35.0. Clinical observations: skin evaluation.
- Remarks:
- Study 3
Applicant's summary and conclusion
- Interpretation of results:
- other: The test chemical was not considered to be sensitizing, since it did not show any effects on the tested subjects.
- Conclusions:
- Based on all the observations and results, it was considered that the test chemical was not sensitizing since it did not show any positive reactions in the tested subjects.
- Executive summary:
Skin Sensitization:
The studies of skin sensitization of the test chemicals are as follows:
Study 2:
The skin sensitization studyof the test chemicalwas performed in 27 volunteers to determine its sensitization potential by maximization test. The study was conducted by using2% of the test chemical in petrolatum, which was used asvehicle and was applied on 27 volunteers and observations were made.All the 27 human volunteers did not show any signs of irritation or sensitization. Thus, from the above observations, the test chemical did not show any skin sensitization potential, since no positive reactions were observed at tested dose levels. Based on all the observations and results, it was concluded that the test chemical was is not likely to be sensitizing, when tested in 27 human volunteers.
Study 3:
The skin sensitization studyof the test chemicalwas performed in 35 guinea pigs to determine its sensitization potential. In this study,2%of test chemical was in petrolatum, which was used as a vehicle was applied on guinea pigs and observations were made. After application of the test chemical, it was observed that no effect of the test chemical was observed in all the 35 animals that were tested. There was no signs of irritation or sensitization which was caused by the test chemical. Thus, based on all the observations and result, it was concluded that the test chemical is not likely to cause any sensitization in guinea pigs when tested in 35 animals.
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