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EC number: 201-662-5 | CAS number: 86-29-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms, other
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data of read across substances
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on two toxicity to micro-organism studies as-
2. and 3. - GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Photobacterium phosphoreum
- Test type:
- static
- Water media type:
- saltwater
- Total exposure duration:
- 30 min
- Test temperature:
- 2. 15ᵒC
3. No data available - pH:
- 2. 5 to 9
3. No data available - Reference substance (positive control):
- yes
- Remarks:
- 2. Recommended reference substance: Phenol and Sodium pentachlorophenate, 3. No data available
- Duration:
- 5 min
- Dose descriptor:
- EC50
- Effect conc.:
- 4.397 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- other: Reduction in light output
- Remarks on result:
- other: 2.
- Duration:
- 15 min
- Dose descriptor:
- EC50
- Effect conc.:
- 4.207 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- other: Reduction in light output
- Remarks on result:
- other: 2.
- Duration:
- 30 min
- Dose descriptor:
- EC50
- Effect conc.:
- 4.601 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Reduction in light output
- Remarks on result:
- other: 2.
- Duration:
- 30 min
- Dose descriptor:
- EC50
- Effect conc.:
- 1.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: 3.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the EC50 value of the test chemical on the luminescence of the test organism Photobacterium phosphoreum can be expected to be 1.3 mg/l and 4.6 mg/l, respectively.
- Executive summary:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxic effect of the test chemical on micro-organisms.The studies are as mentioned below:
Aquatic toxicity study of micro-organism to the test chemical was conducted using Photobacterium phosphoreum, strain NRRL-B-11177 (also referred to asVibrio fischerii, strain NRRL-B-11177). The study was performed at a temperature of 15ᵒC and pH range 5 to 9, respectively. Recommneded reference substance that can be used for the study were Phenol and Sodium pentachlorophenate, respectively. When the test bacterium Photobacterium phosphoreum, strain NRRL-B-11177 was exposed to the test chemical, reduction in light output was observed. Thus, based on this effect, the EC50 value during 5, 15 and 30 min exposure period was determined to be 4.39, 4.2 and 4.6 mg/l, respectively.
For the test chemical, toxicity to microorganism study was carried out for 30 mins. Photobacterium phosphoreum was used as a test organism. On the basis of the effect of test chemical on growth rate, i.e, cell multiplication of the test organism Photobacterium phosphoreum, the EC50 value was determined to be 1.3 mg/l.
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the EC50 value of the test chemical on the luminescence of the test organism Photobacterium phosphoreum can be expected to be 1.3 mg/l and 4.6 mg/l, respectively.
Reference
2.
Table: Toxicity data
# |
5 m- pT |
15 m- pT |
30 m- pT |
Name |
Formula |
ppm |
M. wt. |
164 |
1.49 |
1.51 |
1.47 |
Test chemical |
C8H8O2 |
4.61 |
136.15 |
Where,
Footnote = Purity of chemical (in %) and/or deviation from standard conditions.
pT =Measured concentrations (in log(L/mmol) at which there is a 50% reduction of the light emission relative to controls at the stated exposure times of 5, 15 and 30 min.
ppm =The compound's toxicity expressed in parts per million (ppm) or mg/L. If more than one entry is provided on the same line under the pT headings, preference is given to the 30-min exposure EC50 level, second preference to the 15-min level and third preference to the 5-min level.
3. No data available
Description of key information
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the EC50 value of the test chemical on the luminescence of the test organism Photobacterium phosphoreum can be expected to be 1.3 mg/l and 4.6 mg/l, respectively.
Key value for chemical safety assessment
Additional information
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxic effect of the test chemical on micro-organisms. The studies are as mentioned below:
Aquatic toxicity study of micro-organism to the test chemical was conducted using Photobacterium phosphoreum, strain NRRL-B-11177 (also referred to as Vibrio fischerii, strain NRRL-B-11177). The study was performed at a temperature of 15ᵒC and pH range 5 to 9, respectively. Recommneded reference substance that can be used for the study were Phenol and Sodium pentachlorophenate, respectively. When the test bacterium Photobacterium phosphoreum, strain NRRL-B-11177 was exposed to the test chemical, reduction in light output was observed. Thus, based on this effect, the EC50 value during 5, 15 and 30 min exposure period was determined to be 4.39, 4.2 and 4.6 mg/l, respectively.
For the test chemical, toxicity to microorganism study was carried out for 30 mins. Photobacterium phosphoreum was used as a test organism. On the basis of the effect of test chemical on growth rate, i.e, cell multiplication of the test organism Photobacterium phosphoreum, the EC50 value was determined to be 1.3 mg/l.
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the EC50 value of the test chemical on the luminescence of the test organism Photobacterium phosphoreum can be expected to be 1.3 mg/l and 4.6 mg/l, respectively.
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