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EC number: 201-662-5 | CAS number: 86-29-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin Sensitization:
The skin sensitization study of the test chemicalwas performed in 27 volunteers to determine its sensitization potential by maximization test. .All the 27 human volunteers did not show any signs of irritation or sensitization. Based on all the observations and results, it was concluded that the test chemical was is not likely to be sensitizing, when tested in 27 human volunteers.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Weight of evidence approach based on the available data of the read-across chemicals.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Principles of method if other than guideline:
- Equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- not specified
- Type of study:
- not specified
- Justification for non-LLNA method:
- not specified.
- Species:
- other: Study 2: Human; Study 3: Guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No Data Available
- Positive control results:
- No Data Available
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- 2% in petrolatum (Study 2)
- No. with + reactions:
- 0
- Total no. in group:
- 27
- Clinical observations:
- No effects were observed. (Study 2)
- Remarks on result:
- no indication of skin sensitisation
- Remarks:
- Study 2
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- 2% in petrolatum (Study 3)
- No. with + reactions:
- 0
- Total no. in group:
- 35
- Clinical observations:
- No effects (Study 3)
- Remarks on result:
- other: Reading: 1st reading. Group: test group. Dose level: 2% in petrolatum. No with. + reactions: 0.0. Total no. in groups: 35.0. Clinical observations: skin evaluation.
- Remarks:
- Study 3
- Interpretation of results:
- other: The test chemical was not considered to be sensitizing, since it did not show any effects on the tested subjects.
- Conclusions:
- Based on all the observations and results, it was considered that the test chemical was not sensitizing since it did not show any positive reactions in the tested subjects.
- Executive summary:
Skin Sensitization:
The studies of skin sensitization of the test chemicals are as follows:
Study 2:
The skin sensitization studyof the test chemicalwas performed in 27 volunteers to determine its sensitization potential by maximization test. The study was conducted by using2% of the test chemical in petrolatum, which was used asvehicle and was applied on 27 volunteers and observations were made.All the 27 human volunteers did not show any signs of irritation or sensitization. Thus, from the above observations, the test chemical did not show any skin sensitization potential, since no positive reactions were observed at tested dose levels. Based on all the observations and results, it was concluded that the test chemical was is not likely to be sensitizing, when tested in 27 human volunteers.
Study 3:
The skin sensitization studyof the test chemicalwas performed in 35 guinea pigs to determine its sensitization potential. In this study,2%of test chemical was in petrolatum, which was used as a vehicle was applied on guinea pigs and observations were made. After application of the test chemical, it was observed that no effect of the test chemical was observed in all the 35 animals that were tested. There was no signs of irritation or sensitization which was caused by the test chemical. Thus, based on all the observations and result, it was concluded that the test chemical is not likely to cause any sensitization in guinea pigs when tested in 35 animals.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Skin Sensitisation:
Various studies for read across substances of the target chemical were reviewed for skin sensitisation and are summarized as follows:
Study 2:
The skin sensitization studyof the test chemicalwas performed in 27 volunteers to determine its sensitization potential by maximization test. The study was conducted by using2% of the test chemical in petrolatum, which was used asvehicle and was applied on 27 volunteers and observations were made.All the 27 human volunteers did not show any signs of irritation or sensitization. Thus, from the above observations, the test chemical did not show any skin sensitization potential, since no positive reactions were observed at tested dose levels. Based on all the observations and results, it was concluded that the test chemical was is not likely to be sensitizing, when tested in 27 human volunteers.
Study 3:
The skin sensitization studyof the test chemicalwas performed in 35 guinea pigs to determine its sensitization potential. In this study,2%of test chemical was in petrolatum, which was used as a vehicle was applied on guinea pigs and observations were made. After application of the test chemical, it was observed that no effect of the test chemical was observed in all the 35 animals that were tested. There was no signs of irritation or sensitization which was caused by the test chemical. Thus, based on all the observations and result, it was concluded that the test chemical is not likely to cause any sensitization in guinea pigs when tested in 35 animals.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on all the observations and results from the read-across chemicals, the test chemical was not observed to have skin sensitization potential. Thus, the test chemical is not likely to classify as 'skin sensitizer' as per CLP criteria of classification.
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