Divinylbenzene

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Justification for type of information:

Data is from authorative database

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

To evaluate short term toxicity of test material on fish.

GLP compliance:

not specified

Specific details on test material used for the study:

-IUPAC name: 1,2-di(ethenyl)benzene-Mol. formula: C10H10-Molecular Weight: 131.1969 g/mol- Substance type: Organic- Physical state: Pale, straw-colored liquid

Test organisms (species):

Oryzias latipes

Test type:

static

Water media type:

freshwater

Total exposure duration:

96 h

Reference substance (positive control):

not specified

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

4.2 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Validity criteria fulfilled:

not specified

Conclusions:

The median lethal effect concentration (LC50) was observed to be 4.2 mg/l

Executive summary:

Short term acute toxicity of fish was evaluated for the test chemical 1,2-di(ethenyl)benzene on fish Oryzias latipes for 96 h in static condition . The median lethal effect concentration (LC50) for 50% mortality was observed to be 4.2 mg/l . On the basis of above concentration it can be considered that test material is toxic for fish . Hence, it can be classified as aquatic chronic – 2 as per CLP criteria.

 

Description of key information

Short term toxicity to fish:

Short term acute toxicity of fish was evaluated for the test chemical 1,2-di(ethenyl)benzene on fish Oryzias latipes for 96 h in static condition .The median lethal effect concentration (LC50) for 50% mortality was observed to be 4.2 mg/l . On the basis of above concentration it can be considered that test material is toxic for fish . Hence, it can be classified as aquatic chronic – 2 as per CLP criteria.

 

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

4.2 mg/L

Additional information

Short term toxicity to fish:

Data for target chemical 1,2-di(ethenyl)benzene along with its structurally similar read across substance was used to summarize the short term toxicity of test chemical:

1.Short term acute toxicity of fish was evaluated for the test chemical 1,2-di(ethenyl)benzene on fish Oryzias latipes for 96 h in static condition .The median lethal effect concentration (LC50) for 50% mortality was observed to be 4.2 mg/l . On the basis of above concentration it can be considered that test material is toxic for fish . Hence, it can be classified as aquatic chronic – 2 as per CLP criteria.

2.Short term acute toxicity of fish was evaluated for the test chemical 1,2-di(ethenyl)benzene on fish Oryzias latipes for 48 h in static condition . The median lethal effect concentration (LC50) for 50% mortality was observed to be 3.45 mg/l . On the basis of above concentration it can be considered that test material is toxic for fish . Hence, it can be classified as aquatic chronic – 2 as per CLP criteria.

3.Short term toxicity of test material was evaluate on fish Fathead minnow. A I0 mL aliquot of each sample was transferred to a purge vessel with a 50 mL gastight syringe. Samples outside the calibration range were diluted with deionized water. The test was carried out in sealed containers with little or no head space. LC50 were calculated using the probit method. The slope of the concentration-response curve was also calculated using the probit method.

The median lethal effect concentration (LC50) was observed to be 5.2 mg/l with 95% confidence interval = 4.6 to 5.9 mg/L. Hence , on the basis of the above effect concentration it can be considered that the test chemical is toxic to fish and can be classified in the category aquatic chronic -2 as per CLP criteria