Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from peer reviewed journals

Data source

Reference
Reference Type:
publication
Title:
Contact allergy to various aromatic hydrocarbons
Author:
Steinar Sjöborg et.al
Year:
1982
Bibliographic source:
Contact Dermatitis, 1982

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Guinea pig maximization test
Principles of method if other than guideline:
A guinea pig maximization test was conducted to assess the dermal sensitization potential of the test chemical
GLP compliance:
not specified
Type of study:
guinea pig maximisation test
Justification for non-LLNA method:
Not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Vinyltoluene
EC Number:
246-562-2
EC Name:
Vinyltoluene
Cas Number:
25013-15-4
Molecular formula:
C9H10
IUPAC Name:
1-methyl-2-vinylbenzene
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): Vinyltoluene- Molecular formula : C9H10- Molecular weight : 119.1859 g/ol- Substance type: organic- Physical state: liquid

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
intradermal
Vehicle:
not specified
Concentration / amount:
2.5%
Day(s)/duration:
no data available
Adequacy of induction:
not specified
Route:
epicutaneous, occlusive
Vehicle:
not specified
Concentration / amount:
5%
Day(s)/duration:
no data available
Adequacy of induction:
not specified
Challenge
No.:
#1
Route:
epicutaneous, occlusive
Vehicle:
other: acetone
Concentration / amount:
0.5% w/v in acetone
Adequacy of challenge:
not specified
No. of animals per dose:
15
Details on study design:
no data available
Challenge controls:
no data available
Positive control substance(s):
not specified

Results and discussion

In vivo (non-LLNA)

Results
Reading:
1st reading
Group:
test chemical
Dose level:
0.5% w/v in acetone
No. with + reactions:
0
Total no. in group:
15
Clinical observations:
no reactions observed
Remarks on result:
no indication of skin sensitisation

Applicant's summary and conclusion

Interpretation of results:
other: not sensitizing
Conclusions:
No reactions were observed in 15 guinea pigs tested. Hence, the test chemical can be considered to be not sensitizing to skin.
Executive summary:

A guinea pig maximization test was conducted to assess the dermal sensitization potential of the test chemical. 15 guinea pigs were used for the study. Guinea pigs were intradermally induced with 2.5% of the test chemical and then subjected to topically induction with 5% test chemical. After a suitable rest period, the guinea pigs were challenged with 0.5%w/v in acetone and observed for effects.No reactions were observed in 15 guinea pigs tested. Hence, the test chemical can be considered to be not sensitizing to skin.