Registration Dossier
Registration Dossier
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EC number: 215-325-5 | CAS number: 1321-74-0
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from publication.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Acute toxicity in the rat by using given test chemical
- Author:
- Kennedy et al.
- Year:
- 1 991
- Bibliographic source:
- Toxicology Letters
- Reference Type:
- secondary source
- Title:
- IUCLID dataset for test chemical.
- Author:
- EUROPEAN COMMISSION – European Chemicals Bureau
- Year:
- 2 000
- Bibliographic source:
- IUCLID dataset, EUROPEAN COMMISSION – European Chemicals Bureau 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute inhalation toxicity of 1,2-di(ethenyl)benzene (CAS no: 1321-74-0) in rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Divinylbenzene
- EC Number:
- 215-325-5
- EC Name:
- Divinylbenzene
- Cas Number:
- 1321-74-0
- Molecular formula:
- C10H10
- IUPAC Name:
- 1,2-di(ethenyl)benzene
- Details on test material:
- - IUPAC Name: 1,2-di(ethenyl)benzene- Common Name: Divinylbenzene- InChI: 1S/C10H10/c1-3-9-7-5-6-8-10(9)4-2/h3-8H,1-2H2- Smiles: C=Cc1ccccc1C=C- Molecular formula:C10H10- Molecular weight :131.1969 g/mol- Substance type:Organic- Physical state:liquid
Constituent 1
- Specific details on test material used for the study:
- - IUPAC Name: 1,2-di(ethenyl)benzene- Common Name: Divinylbenzene- InChI: 1S/C10H10/c1-3-9-7-5-6-8-10(9)4-2/h3-8H,1-2H2- Smiles: C=Cc1ccccc1C=C- Molecular formula:C10H10- Molecular weight :131.1969 g/mol- Substance type:Organic- Physical state:liquid
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remark on MMAD/GSD:
- not specified
- Details on inhalation exposure:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 7 h
- Remarks on duration:
- not specified
- Concentrations:
- 351 ppm (351000 mg/m3)
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 351 000 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 7 h
- Remarks on result:
- other: No mortality was observed
- Mortality:
- No mortality was observed in treated rats.
- Clinical signs:
- other: not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute inhalation LC50 value was considered to be >351 ppm (>351000 mg/m3), when rats were treated with 1,2-di(ethenyl)benzene (CAS no: 1321-74-0) via inhalation route for 7 hours.
- Executive summary:
Acute inhalation toxicity study of 1,2-di(ethenyl)benzene (CAS no: 1321-74-0) was conducted in rats at the dose concentration of 351 ppm (351000 mg/m3). No mortality was observed in treated rats. Therefore, LC50 value was considered to be >351 ppm (>351000 mg/m3), when rats were treated with 1,2-di(ethenyl)benzene (CAS no: 1321-74-0) via inhalation route for 7 hours.
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