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Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database.

Data source

Reference
Reference Type:
other: authoritative database
Title:
1,2-di(ethenyl)benzene
Author:
IFA GESTIS
Year:
2018
Bibliographic source:
GESTIS

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute dermal toxicity of 1,2-di(ethenyl)benzene (CAS no: 1321-74-0) in rabbit.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Divinylbenzene
EC Number:
215-325-5
EC Name:
Divinylbenzene
Cas Number:
1321-74-0
Molecular formula:
C10H10
IUPAC Name:
1,2-di(ethenyl)benzene
Details on test material:
- IUPAC Name: 1,2-di(ethenyl)benzene- Common Name: Divinylbenzene- InChI: 1S/C10H10/c1-3-9-7-5-6-8-10(9)4-2/h3-8H,1-2H2- Smiles: C=Cc1ccccc1C=C- Molecular formula :C10H10- Molecular weight :131.1969 g/mol- Substance type:Organic- Physical state:Liquid, colourless- Purity: DVB mixture (55% DVB and 40% ethylvinylbenzene)
Specific details on test material used for the study:
- IUPAC Name: 1,2-di(ethenyl)benzene- Common Name: Divinylbenzene- InChI: 1S/C10H10/c1-3-9-7-5-6-8-10(9)4-2/h3-8H,1-2H2- Smiles: C=Cc1ccccc1C=C- Molecular formula :C10H10- Molecular weight :131.1969 g/mol- Substance type:Organic- Physical state:Liquid, colourless- Purity: DVB mixture (55% DVB and 40% ethylvinylbenzene)

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Type of coverage:
occlusive
Vehicle:
not specified
Details on dermal exposure:
not specified
Duration of exposure:
24 hour
Doses:
4000 and 7950 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
- Other examinations performed: Animals were observed for mortality.
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
7 950 mg/kg bw
Based on:
test mat.
Mortality:
Delayed deaths after 3 days.
Clinical signs:
other: not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The acute dermal LD50 value was considered to be 7950 mg/kg bw, when rabbits were treated with 1,2-di(ethenyl)benzene (CAS no: 1321-74-0) by dermal application occlusively for 24 hour exposure period.
Executive summary:

Acute dermal toxicity study of 1,2-di(ethenyl)benzene (CAS no: 1321-74-0) was conducted in rabbits at the dose concentration of 4000 and 7950 mg/kg bw by dermal occlusive application for 24 hour. Animals were observed for mortality. The animals tolerated doses of approx. 4000 mg/kg bw. Delayed deaths after 3 days were observed. Hence, LD50 value was considered to be 7950 mg/kg bw, when rabbits were treated with 1,2-di(ethenyl)benzene by dermal application occlusively for 24 hour exposure period.