4'-methoxyacetophenone

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2017-05-03 to 2017-05-04

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

GLP compliance:

yes (incl. QA statement)

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

1.79

Temp.:

20 °C

pH:

7.435

Table 1: Results of Log Pow-Values of the test item

Thiourea (dead time)		Retention Time [min]
Solution 1	1^strun	1.320
	2^ndrun	1.320
Solution 2	1^strun	1.320
	2^ndrun	1.320
Test Item		Retention Time [min]	Log k'	Log Pow	Mean	Overall Mean
Solution 1	1^strun	5.967	0.5466	1.790	1.79	1.79 ± 0.00
	2^ndrun	5.960	0.5459	1.789
Solution 2	1^strun	5.960	0.5459	1.789	1.79
	2^ndrun	5.960	0.5459	1.789

The given results represent rounded results obtained by calculation with exact raw data.

Conclusions:

The log Pow of the test item was determined to be 1.79 at 20 °C (HPLC column temperature) and pH 7.435 (Eluent).

Executive summary:

The determination of the partition coefficient (n-octanol/water) of the test item was performed according to the OECD Guideline 117: Partition Coefficient (n-Octanol/Water) : High Performance Liquid Chromatography (HPLC) Method. Elution from a C18 column was achieved using a methanol / water eluent with a retention time in a range of retention times of recommended reference items. Thus, the HPLC method was considered to be appropriate for the test item. Six reference items, listed in the guideline, which have known log Pow-values in the range of 0.5 and 3.4 were used. The log Pow-value of the test item was found to be 1.79 at 20 °C (column temperature) and pH 7.435 (Eluent). The acceptance criterium of the guideline was fulfilled.

Description of key information

The log Pow-value of the test item was assessed according to OECD guideline 117 (HPLC Method) and was found to be 1.79 at 20 °C (column temperature) and pH 7.435 (Eluent).

Key value for chemical safety assessment

Log Kow (Log Pow):

1.79

at the temperature of:

20 °C

Additional information

The determination of the partition coefficient (n-octanol/water) of the test item was performed according to OECD Guideline 117: Partition Coefficient (n-Octanol/Water): High Performance Liquid Chromatography (HPLC) Method. Elution from a C18 column was achieved using a methanol/water eluent with a retention time in a range of retention times of recommended reference items. Six reference items, listed in the guideline, which have known log Pow-values in the range of 0.5 and 3.4 were used. The log Pow-value of the test item was found to be 1.79 at 20 °C (column temperature) and pH 7.435 (Eluent). The acceptance criterium of the guideline was fulfilled.