Registration Dossier
Registration Dossier
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EC number: 202-815-9 | CAS number: 100-06-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975-07-18
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- according to an internal method
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4'-methoxyacetophenone
- EC Number:
- 202-815-9
- EC Name:
- 4'-methoxyacetophenone
- Cas Number:
- 100-06-1
- Molecular formula:
- C9H10O2
- IUPAC Name:
- 1-(4-methoxyphenyl)ethanone
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 1050, 1640, 2050, 2560 and 5000 mg/kg
- No. of animals per sex per dose:
- not specified
- Control animals:
- no
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 720 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1.47 - <= 1.97
- Clinical signs:
- other: At the 5000 mg/kg bw level: lethargy, urinary incontinence, piloerection At lower doses: none
Any other information on results incl. tables
Table: Distrubution of mortality
Dose [g/kg] |
Deaths/No. of animals |
Observation Day |
|||||||||||||
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
||
1.05 |
2/10 |
1 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1.64 |
2/10 |
1 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
2.05 |
6/10 |
3 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
2.56 |
10/10 |
10 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
5.00 |
10/10 |
10 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- In the acute oral toxicity study with doses of 1050, 1640, 2050, 2560 and 5000 mg/kg bw of the test substance, a LD50 of 1720 mg/kg bw was derived.
- Executive summary:
In an orale acute toxicity study, 50 rats were orally exposed once with the test substance at concentrations of 1050, 1640, 2050, 2560 and 5000 mg/kg bw and were observed for a period of 14 days (similar to OECD 401). The LD50 value of the test material was established to be 1720 mg/kg bw.
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