2-Propenoic acid, 2-propylheptyl ester

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics in vivo

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Well-documented publication with acceptable restrictions. Read across was performed with 2-ethylhexyl acrylate. Please refer to IUCLID section 13 for read across justification.

Data source

Reference

Reference Type:

publication

Title:

The disposition of [2,3-14C]-methyl and [2,3-14C]-2-ethylhexyl acrylate in male Wistar albino rats.

Author:

Sapota A

Year:

1988

Bibliographic source:

Arch. Toxicol. 62: 181-184

Materials and methods

Objective of study:

excretion

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Male rats in ten groups of six rats each were administered orally a single dose of 100 mg/kg bw EHA-14C (corresponding to 3.7 mBq/kg bw) in 0.5 mL soybean oil. The animals were placed individually in glass metabolism cages permitting the separate collection of urine, faeces and exhaled air.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2-ethylhexyl acrylate

EC Number:

203-080-7

EC Name:

2-ethylhexyl acrylate

Cas Number:

103-11-7

IUPAC Name:

2-ethylhexyl acrylate

Test material form:

other: liquid

Radiolabelling:

yes

Test animals

Species:

rat

Strain:

Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Sex: male
- Strain: Wistar, albino
- Mean body weight at test start: 220 +/- 30 g

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

other: soybean oil

Duration and frequency of treatment / exposure:

72 hour(s)

Doses / concentrations

Remarks:

Doses / Concentrations:
Males: 100 mg/kg bw (3.7 mBq/kg bw)

No. of animals per sex per dose / concentration:

Males: 6

Control animals:

not specified

Results and discussion

Main ADME results

Main ADME results 1

Type:

metabolism

Results:

Most of the 14C found in the exhaled air was quickly exhaled within the first 3 hrs after administration. Radioactivity was recovered only in the ethanolamine trapping solution, which indicates the presence of 14CO2 rather than unchanged acrylate.

Main ADME results 2

Type:

excretion

Results:

More than 90 % of radioactivity was excreted within 72 hours after administration. The main routes of excretion (50 %) were exhaled air and urine (40 %). Only trace amounts of 14C were excreted in faeces.

Metabolite characterisation studies

Metabolites identified:

no

Any other information on results incl. tables

Elimination of radioactivity derived from [2,3-14C] ethylhexyl acrylate  [% of dose]:

Exhaled air			Urine			Faeces	Total
0-24 h	24-48 h	48-72 h	0-24 h	24-48 h	48-72 h	0-72 h
50.6±6.4	0	0	38.0±4.1	3.2±0.4	0	1.2±0.2	93.0

Mean values of 6 animals plus standard deviation

More than 90 % of radioactivity was excreted within 72 hours after administration. The main routes of excretion (50 %) were exhaled air and urine (40 %). Most of the radioactivity found in urine was excreted within the first 24 hours and excretion by this route increased when the compound was given orally as compared to ip. Only trace amounts of 14C were excreted in faeces. Most of the radioactivity found in the exhaled air was quickly exhaled within the first 3 hours after administration. Radioactivity was recovered only in the ethanolamine trapping solution, which indicates the presence of 14CO2 rather than unchanged acrylate.

The chemical identity of the measured radioactivity (parent compound, metabolites) was not investigated in this study.