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EC number: 250-284-7 | CAS number: 30674-80-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 Jan 1991 - 27 Feb 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- (1981)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- The Department of Health and Social Security of the Government of the United Kingdom
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-isocyanatoethyl methacrylate
- EC Number:
- 250-284-7
- EC Name:
- 2-isocyanatoethyl methacrylate
- Cas Number:
- 30674-80-7
- Molecular formula:
- C7H9NO3
- IUPAC Name:
- 2-isocyanatoethyl methacrylate
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Chales River (UK) Ltd., Manston, Kent, U. K.
- Age at study initiation: approximately 5-8 weeks
- Weight at study initiation: 26-30 g (males), 20-24 g (females)
- Fasting period before study: 2-4 hours prior to gavage and 2 hours after gavage
- Housing: in groups of 5 by sex in solid-floor polypropylene cages with sawdust bedding
- Diet (ad libitum): Rat and Mouse Expanded Diet No. 1, Special Diet Services Limited, Witham, Essex, U. K.
- Water (ad libitum)
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17-24
- Humidity (%): 34-84
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 0.83 ml/kg bw for the high dose group
DOSAGE PREPARATION: The volumes for each dose group were determined according to the specific gravity of the test material and the animals' fasted body weight at the time of dosing. - Doses:
- 500, 707, and 1000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: 0.5, 1, 2, and 4 hours post-dosing, and subsequently once daily until study termination
- Frequency of weighing: on days 0, 7 and 14, or at death
- Necropsy of survivors performed: yes
- Other examinations performed: careful examination of gastro-intestinal tract for signs of corrosion
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 472 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 234 - 953
- Remarks on result:
- other: Deaths are supposed to be contributed to irritation or corrosion of gastro-intestinal tract rather than systemic toxicity.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 149 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 5 - 4 757
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 841 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 707 - 1 000
- Mortality:
- All animals treated at a dose level of 1000 mg/kg bw died the day of dosing or one or two days after dosing. One male and one female were killed in extremis on day 3.
All males treated at a dose level of 707 mg/kg bw died. The deaths occured between one and four days after dosing.
Four males died at a dose level of 500 mg/kg bw. Two of these animals died within 30 min of dosing and the other two animals died one or three days after dosing. Three females treated at a dose level of 500 mg/kg bw died one day after dosing. - Clinical signs:
- other: Common signs of toxicity noted in all dose groups were hunched posture, lethargy, ptosis, laboured respiration, ataxia, and piloerection. Additional signs of loss of righting reflex were noted in animals treated with 707 and 1000 mg/kg bw. Isolated signs
- Gross pathology:
- Abnormalities generally seen at necropsy of animals that died during the study were haemorrhagic or abnormally red lungs, dark liver or patchy pallor of the liver and dark kidneys.
Commonly noted effects on the gastro-intestinal tract were haemorrhage of the small intestines and gastric mucosa. Haemorrhage of the large intestine was noted in one male treated with 500 mg/kg bw and one male and two females treated with 1000 mg/kg bw; sloughing of the non-glandular epithelium was noted in three males treated with 500 mg/kg bw and one male and two females treated with 1000 mg/kg bw.
No abnormalities were in one male and two females treated with 500 mg/kg bw and all females treated with 707 mg/kg bw that were killed at the ned of the study.
A necropsy was not performed on one male that died after a dose of 707 mg/kg bw. This omission was due to an oversight but was considered not to affect the purpose or integrity of the study.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS Category 4 (H302) according to Regulation (EC) No 1272/2008
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