Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 421-140-2 | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
SUMMARY / CONCLUSION
The physicochemical properties of RSS-4, notably its high water solubility and octanol/water partition coefficient of 1.5, suggest that RSS-4 will be readily absorbed from the gastrointestinal tract. This is supported by experimental data which observed liver and kidney effects after oral exposure. Related to the metabolisation, so far no studies have been identified in the literature or performed with RSS-4. However, experimental information has been found on the acid and on the equivalent calcium salt. While in the body, these compounds may undergo (1) a glucuronidation to form a glucuronic acid conjugate; (2) a ß-oxidation to yield acetylethyl-acetic acid following by a decarboxylation; (3) a dealkylation in some diabetic human. The metabolites will be then excreted in urine.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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