Registration Dossier
Registration Dossier
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EC number: 946-245-5 | CAS number: -
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Body burden: For long-term fish toxicity, the NOEC is derived using the Lethal and Critical Body burden approach as described in the ECHA R.7b Guidance Appendix 7.8-3 (2017) using the structure, molecular weight, short-term toxicity to fish and the aquatic bioconcentration factor (BCF) as input data. The substance is identified as a vinyl/allyl/propargyl ketone organic substance in ECOSAR 2.0. According to the referenced studies in ECOSAR 2.0, the effects of this chemical class on fish, daphnia and algae are not expressing excess toxicity compared to neutral organics. These vinyl/allyl/propargyl ketone chemicals may be acting in a manner similar to neutral organics. Therefore, the substance is assumed to follow a non-polar (Type I) narcotic mode of action (acute = 1 to 10 mmol.kg-1 , chronic = 0.1 to 1 mmol.kg-1; Thompson and Stewart 2003).
The Lethal Body Burden (LBB) approach for the substance is calculated first to see which mMol/kg is applicable for the CBB approach. The used equation for long-term fish toxicity is CBB mMol/kg fish = NOEC mMol/L x BCF. The CBB is estimated to between 0.1 and 1 mMol/kg fish. The LBB (LBB mMol/kg fish = LC50 mMol/L x BCF) calculation for the substance results in 8.84 mMol/kg fish (using LC50 of 4.8 mg/L, BCF of 335 and a molecular weight of 182). This LBB value shows that for the CBB approach, the 0.884 mMol/kg fish can be used (instead of 0.1 or 1 mMol/kg fish). The long-term fish NOEC thus becomes 0.48 mg/L (0.884 mMol/kg = NOEC mMol/L x 335 (molecular weight 182).
Uncertainty of the predictions in LBB/CBB approach:
The LBB and CBB approaches are most applicable to the narcotic type of chemicals. As described above, based on the structure, the substance is a vinyl/allyl/propargyl ketones organic substance. This chemical class was predicted to act in a manner similar to neutral organics, and was observed to not express excess toxicity compared to neutral organics, according to ECOSAR 2.0. Thus, the substance is not assumed to have a specific mode of action in the LBB/CBB calculations. The short-term toxicity to fish and aquatic bioaccumulation studies have been performed with the same fish species. Furthermore, the BCF used here is normalised to 5% lipid content which should diminish any further uncertainty. In view of the reasoning above, the uncertainty of the CBB prediction is limited. The derived long-term fish toxicity of the substance is considered reliable.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- NOEC
- Effect concentration:
- 0.48 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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