Registration Dossier
Registration Dossier
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EC number: 946-245-5 | CAS number: -
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The toxicity of the test substance to
microorganisms was determined in an activated sludge respiration
inhibition test according to OECD TG 209 in compliance with GLP. In this
study, sludge from a local municipal sewage treatment plant receiving
predominantly domestic sewage was exposed to loading rates of 0, 46,
100, 220, 460 or 1000 mg/L for 3 hours. No statistically significant
inhibition of the respiration rate of the sludge was recorded at or
below a loading rate of 220 mg test substance/litre. At higher loading
rates the inhibitory effect of the test substance on activated sludge
bacteria increased with increasing loading rate, ranging from an average
of 36% inhibition at a loading rate of 460 mg/L to an average of 49% at
a loading rate of 1000 mg/L. Based on these findings, the 3-h EC50 value
and 3-h NOEC were determined at 910 and 220 mg/L, respectively. The
study met the acceptability criteria prescribed by the protocol and was
considered valid.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 910 mg/L
- EC10 or NOEC for microorganisms:
- 220 mg/L
Additional information
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