Registration Dossier
Registration Dossier
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EC number: 610-461-5 | CAS number: 495-61-4
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Single intraperitoneal administration to mice
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 2-methyl-6-(4-methylcyclohex-3-en-1-ylidene)hept-2-ene
- EC Number:
- 207-805-8
- EC Name:
- 2-methyl-6-(4-methylcyclohex-3-en-1-ylidene)hept-2-ene
- Cas Number:
- 495-62-5
- Molecular formula:
- C15H24
- IUPAC Name:
- 4-(1,5-dimethylhex-4-en-1-ylidene)-1-methylcyclohexene
- Reference substance name:
- (4S)-1-methyl-4-(6-methylhepta-1,5-dien-2-yl)cyclohexene
- EC Number:
- 610-461-5
- Cas Number:
- 495-61-4
- Molecular formula:
- C15H24
- IUPAC Name:
- (4S)-1-methyl-4-(6-methylhepta-1,5-dien-2-yl)cyclohexene
- Reference substance name:
- 6-methyl-2-(4-methylcyclohex-3-enyl)hept-2,5-diene
- EC Number:
- 241-610-9
- EC Name:
- 6-methyl-2-(4-methylcyclohex-3-enyl)hept-2,5-diene
- Cas Number:
- 17627-44-0
- Molecular formula:
- C15H24
- IUPAC Name:
- 4-(1,5-dimethylhexa-1,4-dien-1-yl)-1-methylcyclohexene
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Remarks:
- Wiga
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Mean weights at study initiation: 28 g (males), 28 g (females)
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on exposure:
- Concentration in vehicle: 2%, 7%, 20% emulsion of 0.5% aqueous carboxymethylcellulose formulation
Application volume: 10 ml/kg - Doses:
- 200, 700, 2000 mg/kg
- No. of animals per sex per dose:
- 5 males / 5 females (700, 2000 mg/kg)
2 males (200 mg/kg) - Control animals:
- other: not applicable
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Clinical signs including body weight: yes
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- 2000 mg/kg bw: 2/10
700 mg/kg bw: 0/10
200 mg/kg bw: 0/2 - Clinical signs:
- bad general condition, apathy, dispnoe, spastic gait, convulsions
- Body weight:
- 2000 mg/kg bw slight body weight loss
- Gross pathology:
- No test substance related findings reported
Any other information on results incl. tables
In a pretest, application of 200 and 2000 mg/kg bw resulted in a mortality of 0/2 and 2/2 males, respectively.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
