long chain alkyl thio carbamide metal complex

Vapour pressure

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

22 September 1999 to 08 October 1999

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

yes

Remarks:

no correction made for temperature and pressure difference between saturator column and flow meter

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

GLP compliance:

yes

Type of method:

gas saturation method

Temp.:

30 °C

Vapour pressure:

0.032 Pa

Remarks on result:

other: Measured

Temp.:

40 °C

Vapour pressure:

0.087 Pa

Remarks on result:

other: Measured

Temp.:

50 °C

Vapour pressure:

0.132 Pa

Remarks on result:

other: Measured

Key result

Temp.:

25 °C

Vapour pressure:

0.024 Pa

Remarks on result:

other: Estimated based on linear regression analysis of measured vapour pressure at temperatures of 30, 40 and 50 degrees centigrade

Conclusions:

In a GLP study conducted according to OECD Guideline 104, the estimated vapour pressure of EC# 434-650-5 test material at 25oC, based on linear regression analysis of the log p versus 1/T curve generated from measured vapour pressures at 30, 40 and 50oC, was 0.0236 Pa.

Executive summary:

In a GLP study conducted according to OECD Guideline 104 and EC Method A.4, the vapour pressure of EC# 434-650-5 test material was determined by the gas saturation method. Briefly, the neat test material was coated onto glass beads, which were transferred to a saturator column and subject to a stream of inert carrier gas (N2) at a constant temperature (+/- 0.5 degrees centigrade). The resulting vapour-saturated gas was passed through XAD-2 sorbent tubes to absorb the MRD-99-422, which was then extracted with methylene chloride. Gas chromatography was used to determine the quantity of test substance transferred. Triplicate determinations were carried out at 30, 40 and 50^oC. The gas flow rates were 100 ml/min at the two higher temperatures or 200 ml/min at the lowest temperature.

The mean vapour pressures at 30, 40 and 50^oC were 0.0318, 0.0874 and 0.132 Pa, respectively. Based on linear regression analysis of the log p versus 1/T curve of these measurements, the estimated vapour pressure at 25^oC is 0.0236 Pa.

Reference 2

Endpoint:

vapour pressure

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Reason / purpose for cross-reference:

read-across source

Test no.:

#1

Temp.:

30 °C

Vapour pressure:

0.032 Pa

Test no.:

#2

Temp.:

40 °C

Vapour pressure:

0.087 Pa

Test no.:

#3

Temp.:

50 °C

Vapour pressure:

0.132 Pa

Key result

Temp.:

25 °C

Vapour pressure:

0.024 Pa

Remarks on result:

other: estimated based on linear regression analysis from measured vapour pressures at 30, 40 and 50 degrees C

Conclusions:

In a GLP study conducted according to OECD Guideline 104 and EC Method A.4, the vapour pressure of EC# 434-650-5 test material was determined by the gas saturation method. Briefly, the neat test material was coated onto glass beads, which were transferred to a saturator column and subject to a stream of inert carrier gas (N2) at a constant temperature (+/- 0.5 degrees centigrade). The resulting vapour-saturated gas was passed through XAD-2 sorbent tubes to absorb the MRD-99-422, which was then extracted with methylene chloride. Gas chromatography was used to determine the quantity of test substance transferred. Triplicate determinations were carried out at 30, 40 and 50oC. The gas flow rates were 100 ml/min at the two higher temperatures or 200 ml/min at the lowest temperature.

The mean vapour pressures at 30, 40 and 50oC were 0.0318, 0.0874 and 0.132 Pa, respectively. Based on linear regression analysis of the log p versus 1/T curve of these measurements, the estimated vapour pressure at 25oC is 0.0236 Pa.

Executive summary:

In view of the structural and chemical similarities, it is considered that the results of this study can be used for read-across to EC# 457-320-2.

Reference 3

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

8 March to 1 June 2000

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

GLP compliance:

yes

Type of method:

effusion method: vapour pressure balance

Specific details on test material used for the study:

Appearance: dark red paste
Storage conditions: Room temperature in the dark
Batch: NB 6786-35

Key result

Test no.:

#3

Temp.:

25 °C

Vapour pressure:

0 Pa

Key result

Test no.:

#4

Temp.:

25 °C

Vapour pressure:

0 Pa

Test no.:

#1

Temp.:

25 °C

Vapour pressure:

0.002 Pa

Remarks on result:

other: disregarded due to poor linear relationship and evidence of degassing

Test no.:

#2

Temp.:

25 °C

Vapour pressure:

0 Pa

Remarks on result:

other: Disregarded due to poor linear relationship and evidence of degassing

Runs 1 and 2 are disregarded due to the poor linear relationship obtained and evidence of degassing. The mean vapour pressure of 3.4 10 -6 Pa at 25 degrees C was obtained from runs 3 and 4.

Conclusions:

The vapour pressure of the test substance is 3.6 x 10-6 Pa at 25 degrees C.

Executive summary:

The vapour pressure of a substance is defined as the saturation pressure above a solid or liquid substance. At the thermodynamic equilibrium, the vapour pressure of a pure substance is a function of temperature only.

The vapour pressure was determined using a vapour pressure balance. 0.35g of test substance was added to the furnace, the apparatus assembled and evacuated to a pressure of less than 1 x 10 -4 Torr. A series of 4 runs were performed between temperatures and 33 and 181 degrees C. As no condensation occurred, the vapour pressure is related to only to the observed mass difference.

The mean vapour pressure of 3.4 x 10 -6 Pa was obtained from two liner plots (runs 3 and 4) - runs 1 and 2 were disregarded due to the poor linear relationship obtained and evidence of degassing.

Therefore, the vapour pressure of the test substance is 3.4 x10 -6 Pa at 25 degrees C.

Based on the physical chemical similarities, this study is considered suitable for read-across to EC:457 -320 -2.

Reference 4

Endpoint:

vapour pressure

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reason / purpose for cross-reference:

read-across source

Test no.:

#1

Temp.:

25 °C

Vapour pressure:

0.002 Pa

Remarks on result:

other: Disregared due to poor linear relationship and evidence of degassing

Test no.:

#2

Temp.:

25 °C

Vapour pressure:

0 Pa

Remarks on result:

other: Disregarded due to poor linear relationship and evidence of degassing

Key result

Test no.:

#3

Temp.:

25 °C

Vapour pressure:

0 Pa

Key result

Test no.:

#4

Temp.:

25 °C

Vapour pressure:

0 Pa

Runs 1 and 2 are disregarded due to the poor linear relationship obtained and evidence of degassing. Therefore, the mean vapour pressure of 3.4 10 -6 Pa at 25 degrees C was obtained from runs 3 and 4.

Conclusions:

The vapour pressure of the test substance is 3.4 x 10-6 Pa at 25 degrees C.

Executive summary:

The vapour pressure of a substance is defined as the saturation pressure above a solid or liquid substance. At the thermodynamic equilibrium, the vapour pressure of a pure substance is a function of temperature only.

The vapour pressure was determined using a vapour pressure balance. 0.35g of test substance was added to the furnace, the apparatus assembled and evacuated to a pressure of less than 1 x 10 -4 Torr. A series of 4 runs were performed between temperatures and 33 and 181 degrees C. As no condensation occurred, the vapour pressure is related to only to the observed mass difference.

The mean vapour pressure of 3.4 x 10 -6 Pa was obtained from two liner plots (runs 3 and 4) - runs 1 and 2 were disregarded due to the poor linear relationship obtained and evidence of degassing.

Therefore, the vapour pressure of the test substance is 3.4 x10 -6 Pa at 25 degrees C.

Description of key information

There are 2 vapour pressure results available on EC: 434 -650 -5 which are considered suitable for read-across to EC: 457 -320 -2.

In a supporting GLP study (1999) conducted according to OECD Guideline 104, the estimated vapour pressure of EC# 434-650-5 test material at 25oC, based on linear regression analysis of the log p versus 1/T curve generated from measured vapour pressures at 30, 40 and 50oC, was 0.0236 Pa.

A key GLP study is available conducted according to OECD 104 (2000). The mean vapour pressure of 0.0000034 Pa on EC: 434 -650 -5 was obtained via vapour pressure balance method. This result can be read-across to EC: 457 -320 -2 and is used for the purposes of the chemical safety assessment.

Key value for chemical safety assessment

Vapour pressure:

0 Pa

at the temperature of:

25 °C