Registration Dossier
Registration Dossier
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EC number: 457-320-2 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004-04-23 to 2004-06-02
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- other: UV spectrophotometry
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 5.1
- Temp.:
- 20 °C
- pH:
- >= 5.57 - <= 6.36
- Remarks on result:
- other: mean log Pow of six determinations
- Details on results:
- The HPLC calibration was linear up to 100 mg test material/l and that for the UV spectrophotometry up to 20 mg/l, with regression coefficients of 0.9997 and 0.9954 respectively. The mean value for log 10Pow for six replicate determinations was greater than 5.1
- Conclusions:
- In a GLP study conducted according to OECD guideline 107, the octanol:water partition coefficient (log10Pow) for MRD-02-375 (EC# 457-320-2) was greater than 5.1 at 20oC.
- Executive summary:
In a GLP study conducted according to OECD guideline 107, the n-octanol:water partition coefficient of EC# 457-320-2 (MRD-02-375) was determined using the shake-flask method. Concentrations of the test material in the organic phase were determined by HPLC and in the aqueous phase by UV spectrophotometry.
The HPLC calibration was linear up to 100 mg test material/l and that for the UV spectrometry up to 20 mg/l, with regression coefficients of 0.9997 and 0.9954 respectively. The mean value for log 10Pow for six replicate determinations was greater than 5.1 at 20oC.
Reference
Description of key information
In a GLP study conducted according to OECD guideline 107, the octanol:water partition coefficient (log10Pow) for EC# 457-320-2 was greater than 5.1 at 20oC.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 5.1
- at the temperature of:
- 20 °C
Additional information
A GLP study is also available on a similar chemical, EC: 434 -650 -5, which also demonstrates a log Pow > 4.81.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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