long chain alkyl thio carbamide metal complex

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1999-09-14 to 1999-09-15

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

yes

Remarks:

but with Molybdenum analyses performed in a non-GLP compliant facility

Type of method:

column elution method

Key result

Water solubility:

< 0.31 mg/L

Temp.:

19.72 °C

pH:

ca. 5.2 - ca. 5.7

Remarks on result:

other: pH of samples at end of each 'run': 5.2 and 5.7

Details on results:

The Mo content of all fractions eluted from the 1st run and 7 out of 8 fractions eluted from the 2nd run was < 0.0250 ppm or <0.31 mg test material/l.
The Mo content of the first fraction from the 2nd run was 0.0636 ppm (0.777 mg test material/l); this value was not used in the calculation of the solubility of MRD-99-422.

Conclusions:

Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L) Below practical limit of quantitation (PQL)
In a GLP study conducted according to OECD guideline 105, the water solubility of MRD-99-422 (EC# 434-650-5) was less than 0.31 mg/l at 20oC.

Executive summary:

In a GLP study conducted according to OECD guideline 105, the water solubility of MRD-99-422 (EC# 434-650-5) was determined by micro-column elution from Chromosorb WHP carrier at approximately 20oC. Samples eluted from the column were analysed for Mo content by ICP-AES, and the concentration of test material determined after normalisation for dilution factor and Mo content (9.17%) of MRD-99-422.

The water solubility of MRD-99-422 was less than the practical quantitation limit (PQL) of the assay of 0.31 mg/l at 20oC.

In view of the structural and chemical similarities, it is considered that the results of this study can be used for read-across to EC# 457-320-2.

Reference 2

Endpoint:

water solubility

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Reason / purpose for cross-reference:

read-across source

Key result

Water solubility:

< 0.31 mg/L

Conc. based on:

test mat.

Incubation duration:

> 17 - <= 70 h

Temp.:

20 °C

pH:

ca. 6.7

Conclusions:

Interpretation of results: slightly soluble (0.1-100 mg/L) Below practical limit of quantitation (PQL)
In a GLP study conducted according to OECD guideline 105, the water solubility of MRD-99-422 (EC# 434-650-5) was less than 0.31 mg/l at 20oC.

Executive summary:

In a GLP study conducted according to OECD guideline 105, the water solubility of MRD-99-422 (EC# 434-650-5) was determined by micro-column elution from Chromosorb WHP carrier at approximately 20oC. Samples eluted from the column were analysed for Mo content by ICP-AES, and the concentration of test material determined after normalisation for dilution factor and Mo content (9.17%) of MRD-99-422.

The water solubility of MRD-99-422 was less than the practical quantitation limit (PQL) of the assay of 0.31 mg/l at 20oC.

In view of the structural and chemical similarities, it is considered that the results of this study can be used for read-across to EC# 457-320-2.

Reference 3

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

21 April 2004 - 27 May 2004

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

column elution method

Key result

Water solubility:

< 0.31 mg/L

Conc. based on:

test mat.

Incubation duration:

> 17 - <= 70 h

Temp.:

20 °C

pH:

ca. 6.7

Details on results:

The calibration was found to be linear over the range of 0 to 2 ppm of standard molybdenum solutions with regression coefficient of 1.0000. The practical limit of quantification was considered to be 0.025 ppm.
The test shows that the water solubility is less than 0.31 mg/L.

Conclusions:

EC# 457-320-2 was found to have a water solubility of less than 0.31 mg/L at 20 degrees C.

Executive summary:

The method followed to determine the water solubility of the test substance was in accordance with OECD 105 and to GLP. The test substance was found to have a water solubility of less than 0.31 mg/L at 20 degrees C.

Description of key information

EC# 457 -320 -2 was found to have a water solubility study of less than 0.31 mg/L at 20 degrees C in accordance to OECD 105 and to GLP.

Key value for chemical safety assessment

Water solubility:

0.31 mg/L

at the temperature of:

20 °C

Additional information

In a GLP study conducted according to OECD guideline 105, the water solubility of MRD-99-422 (EC# 434-650-5) was found to be also less than 0.31 mg/l at 20oC. In view of the structural and chemical similarities, it is considered that the results of this study can be used for read-across to EC# 457-320-2.