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EC number: 204-428-0 | CAS number: 120-82-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_physical-and-chemical-properties.png)
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- not specified
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Original report not available
- Justification for type of information:
- Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
- Principles of method if other than guideline:
- secondary peer reviewed scoure, valid collection af data
- GLP compliance:
- not specified
- Type of method:
- other: no data
- Partition coefficient type:
- other: no data
- Specific details on test material used for the study:
- analytical purity: not specified
- Type:
- log Pow
- Partition coefficient:
- 3.92
- Remarks on result:
- other: Temperature and pH value were not reported.
- Type:
- log Pow
- Partition coefficient:
- 3.98
- Remarks on result:
- other: Temperature and pH value were not reported.
- Executive summary:
William/ Meylan, 1993
The logPow of 1,2,4-trichlorobenzene is reported as 3.92 and 3.98. Temperature and pH value were not reported.
- Endpoint:
- partition coefficient
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Original report not available
- Justification for type of information:
- Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
- Principles of method if other than guideline:
- secondary peer reviewed scoure, valid collection af data
- GLP compliance:
- not specified
- Type of method:
- other: no data
- Partition coefficient type:
- other: no data
- Specific details on test material used for the study:
- analytical purity: not specified
- Type:
- log Pow
- Partition coefficient:
- 4.161
- Remarks on result:
- other: Temperature and pH value were not reported.
- Executive summary:
Leo, 1991
The estimated by calculation logPow of 1,2,4-trichlorobenzene is reported as 4.161. Temperature and pH value were not reported.
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication which meets basic scientific principles. Adopted according to EU Risk Assessment (public available peer reviewed source).
- Justification for type of information:
- Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 123 (Partition Coefficient (1-Octanol / Water), Slow-Stirring Method)
- Deviations:
- yes
- Remarks:
- : following values were not reported: Exact volumes of 1-octanol and water, exact volumes of the samples, exact concentrations of the test substance in water and octanol, number of replicates, concentrations as function of time.
- GLP compliance:
- not specified
- Type of method:
- other: slow-stirring method
- Partition coefficient type:
- octanol-water
- Analytical method:
- other: GC or HPLC
- Type:
- log Pow
- Partition coefficient:
- 4.05
- Temp.:
- 25 °C
- Remarks on result:
- other: No further data on pH value.
- Details on results:
- log Pow: 4.050 +/- 0.018
- Executive summary:
de Bruijn J, 1989
Octanol/water partition coefficient for 1,2,4-trichlorobenzene was determined with the "slow-stirring" method similiar to OECD 123.
log Pow of 1,2,4-trichlorobenzene: 4.050 +/- 0.018 at 25°C.
- Endpoint:
- partition coefficient
- Type of information:
- not specified
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Original report not available
- Justification for type of information:
- Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
- Principles of method if other than guideline:
- secondary peer reviewed scoure, valid collection af data
- GLP compliance:
- not specified
- Type of method:
- other: no data
- Partition coefficient type:
- other: no data
- Specific details on test material used for the study:
- analytical purity: not specified
- Type:
- log Pow
- Partition coefficient:
- 4.22
- Remarks on result:
- other: Temperature and pH value were not reported.
- Executive summary:
DeKock, 1987
The logPow of 1,2,4-trichlorobenzene is reported as 4.22. Temperature and pH value were not reported.
- Endpoint:
- partition coefficient
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Original report not available
- Justification for type of information:
- Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
- Principles of method if other than guideline:
- calculated: MACCS (fragment-addition method)
- GLP compliance:
- not specified
- Type of method:
- calculation method (fragments)
- Partition coefficient type:
- other: no data
- Type:
- log Pow
- Partition coefficient:
- 4.28
- Remarks on result:
- other: Temperature and pH value were not reported.
- Details on results:
- estimated by calculation
- Executive summary:
Eadsforth, 1986
The measured logPow of 1,2,4-trichlorobenzene is reported as 4.28. Temperature and pH value were not reported.
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Justification for type of information:
- Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- yes
- Remarks:
- : volume of the octanol-water-system 40 ml instead of 200 ml; 14C-analysis
- Principles of method if other than guideline:
- secondary peer reviewed scoure, valid collection af data
- GLP compliance:
- not specified
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- analytical purity: not specified
- Type:
- log Pow
- Partition coefficient:
- 3.63
- Temp.:
- 20 °C
- Remarks on result:
- other: The pH was not reported.
- Executive summary:
Korte, 1986
The measured logPow with the flask method (OECD 107) of 1,2,4-trichlorobenzene is reported as 3.63 at 20 °C. The pH value was not reported.
- Endpoint:
- partition coefficient
- Type of information:
- not specified
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Original report not available
- Justification for type of information:
- Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
- Principles of method if other than guideline:
- secondary peer reviewed scoure, valid collection af data
- GLP compliance:
- not specified
- Type of method:
- other: no data
- Partition coefficient type:
- other: no data
- Specific details on test material used for the study:
- analytical purity: not specified
- Type:
- log Pow
- Partition coefficient:
- 2.33
- Remarks on result:
- other: Temperature and pH value were not reported.
- Executive summary:
UBA, 1984
The measured logPow of 1,2,4-trichlorobenzene is reported as 2.33. Temperature and pH value were not reported.
- Endpoint:
- partition coefficient
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Original report not available
- Justification for type of information:
- Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
- Principles of method if other than guideline:
- secondary peer reviewed source, valid collection af data
- GLP compliance:
- not specified
- Type of method:
- other: no data
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- 4.26
- Remarks on result:
- other: Temperature and pH value were not reported.
- Executive summary:
UBA, 1984
The calculated logPow of 1,2,4-trichlorobenzene is reported as 4.26. Temperature and pH value were not reported.
- Endpoint:
- partition coefficient
- Type of information:
- not specified
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Original report not available
- Justification for type of information:
- Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
- Principles of method if other than guideline:
- secondary peer reviewed scoure, valid collection af data
- GLP compliance:
- not specified
- Type of method:
- other: no data
- Partition coefficient type:
- other: no data
- Specific details on test material used for the study:
- analytical purity: not specified
- Type:
- log Pow
- Partition coefficient:
- 4.21
- Remarks on result:
- other: Temperature and pH value were not reported.
- Executive summary:
Hoshikawa, 1983
The logPow of 1,2,4-trichlorobenzene is reported as 4.21. Temperature and pH value were not reported.
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Original report not available
- Justification for type of information:
- Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
- Principles of method if other than guideline:
- secondary peer reviewed scoure, valid collection af data
- GLP compliance:
- not specified
- Type of method:
- other: no data
- Partition coefficient type:
- other: no data
- Specific details on test material used for the study:
- analytical purity: not specified
- Type:
- log Pow
- Partition coefficient:
- 4.23
- Remarks on result:
- other: Temperature and pH value were not reported.
- Executive summary:
Hooftman, 1982
The measured logPow of 1,2,4-trichlorobenzene is reported as 4.23. Temperature and pH value were not reported.
- Endpoint:
- partition coefficient
- Type of information:
- not specified
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Original report not available
- Justification for type of information:
- Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
- Principles of method if other than guideline:
- secondary peer reviewed scoure, valid collection af data
- GLP compliance:
- not specified
- Type of method:
- other: no data
- Partition coefficient type:
- other: no data
- Specific details on test material used for the study:
- analytical purity: not specified
- Type:
- log Pow
- Partition coefficient:
- 4.12
- Remarks on result:
- other: Temperature and pH value were not reported.
- Executive summary:
Koenemann, 1979
The estimated logPow of 1,2,4-trichlorobenzene is reported as 4.12. Temperature and pH value were not reported.
Referenceopen allclose all
estimated by calculation
temperature: 20 - 22°C
Description of key information
The individual study reports (data from handbooks or collection of data and (QSAR)calculations) show some deficiencies with respect to the comprehensiveness of the experimental details. Therefore, a reliability of 1 or 2 and thus adequacy as key study was not assignable for any of the individual studies. Consequently, the studies were assigned a Klimisch score of 4 (according to guidance document R.4, ‘not assignable: studies or data […] which are only listed in short abstracts or secondary literature (books, reviews, etc.)). As the individual studies report values are in a similar range, collectively, these studies can be used to conclude on this endpoint and to satisfy the information requirement.
The partition coefficient of 1,2,4-trichlorobenzene was determined in a series of experimental studies and calculations and found to be in the range of 2.33-4.28.
The logKow of 4.28 was chosen as key value for chemical safety assessment (worst case approach).
William/ Meylan, 1993
The logPow of 1,2,4-trichlorobenzene is reported as 3.92 and 3.98. Temperature and pH value were not reported.
Leo, 1991
The estimated by calculation logPow of 1,2,4-trichlorobenzene is reported as 4.161. Temperature and pH value were not reported.
de Bruijn J, 1989
Octanol/water partition coefficient for 1,2,4-trichlorobenzene was determined with the "slow-stirring" method similiar to OECD 123. log Pow of 1,2,4-trichlorobenzene: 4.050 +/- 0.018 at 25°C.
DeKock, 1987
The measured logPow of 1,2,4-trichlorobenzene is reported as 4.22. Temperature and pH value were not reported.
Eadsforth, 1986
The measured logPow of 1,2,4-trichlorobenzene is reported as 4.28. Temperature and pH value were not reported.
Korte, 1986
The measured logPow with the flask method (OECD 107) of 1,2,4-trichlorobenzene is reported as 3.63 at 20 °C. The pH value was not reported.
UBA, 1984
The measured logPow of 1,2,4-trichlorobenzene is reported as 2.33. Temperature and pH value were not reported.
UBA, 1984
The calculated logPow of 1,2,4-trichlorobenzene is reported as 4.26. Temperature and pH value were not reported.
Hoshikawa, 1983
The logPow of 1,2,4-trichlorobenzene is reported as 4.21. Temperature and pH value were not reported.
Hooftman, 1982
The measured logPow of 1,2,4-trichlorobenzene is reported as 4.23. Temperature and pH value were not reported.
Koenemann, 1979
The estimated logPow of 1,2,4-trichlorobenzene is reported as 4.12. Temperature and pH value were not reported.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 4.28
Additional information
pH and temperature were not reported
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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