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EC number: 204-428-0 | CAS number: 120-82-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- other: EU Risk Assessment
- Adequacy of study:
- other information
- Reliability:
- other: EU Risk Assessment
- Rationale for reliability incl. deficiencies:
- other: no reliability is given as this is a summary entry for the EU RAR
- Principles of method if other than guideline:
- EU Risk Assessment
- GLP compliance:
- not specified
- Executive summary:
EU Risk Assessment, 2003:
Reported NOEC range between 0.064 mg/l (US EPA, 1988) and 0,36 mg/l (Richter et al., 1983). Values for EC50 range between 0.6 mg/l (Hermens et al., 1984) and 0.45 mg/l (Calamari et al., 1983).
The daphnia test by Calamari et al. (1983) was performed under semi-static conditions (test medium changed every other day), in a closed system and the measured concentration did not deviate more than 15% from the initial concentration.
In a study by Hermens et al. (1984) on the sublethal toxicity to Daphnia magna, the 16-day LC50 on mortality was 0.56 mg/l and the EC50 on reproduction was 0.27 mg/l (reported asµmol/l inthe reference). In an identical 16-day experiment, measurements of the test concentrations are stated to average 58% of nominal (Hermens et al., 1985) and the 16-day EC50 was 0.52 mg/l.The results are not corrected for the measured concentrations. Assuming the average concentration was the same in the two experiments, the 16 -day LC50 was 0.32 mg/l, EC50 0.16 mg/l and the NOEC on mortality and reproduction 0.19 mg/l and 0.06 mg/l, respectively.
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- other: BUA report
- Adequacy of study:
- other information
- Reliability:
- other: BUA report
- Rationale for reliability incl. deficiencies:
- other: no reliability is given as this is a summary entry for the BUA report
- Principles of method if other than guideline:
- BUA report
- GLP compliance:
- not specified
- Executive summary:
BUA report, 1987
The most critical reported NOEC for Daphnia is 0.1 mg/l for the extended life cycle test (Hermens et al., 1984).
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Original reference not available.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- Version / remarks:
- Cited as OECD Guide-line 202, part 2 (Daphnia sp., Reproduction Test)
- GLP compliance:
- not specified
- Test organisms (species):
- Daphnia magna
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 3.4 mg/L
- Basis for effect:
- reproduction
- Executive summary:
Yoshioka, 1993
In a reproduction test conducted OECD Guideline 211 and OECD Guideline 202, part 2 with Daphnia magna, a 21 d-NOEC of 0.7 mg/L was determined.
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1995
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- GLP-Guideline study, only results are published, study report not available.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- Deviations:
- not specified
- GLP compliance:
- yes
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Daphnia magna
- Water media type:
- freshwater
- Limit test:
- no
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- 0.1 - 0.32 mg/L
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.1 mg/L
- Executive summary:
NITE Japan, 2009
In a reproduction test, with Daphnia magna a 21 d NOEC of 0.1 mg/L and a 21 d EC50 of 0.1 - 0.32 mg/L were determined.
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Original reference not available.
- GLP compliance:
- not specified
- Analytical monitoring:
- yes
- Test organisms (species):
- Daphnia magna
- Duration:
- 28 d
- Dose descriptor:
- EC50
- Effect conc.:
- 0.36 - 0.6 mg/L
- Executive summary:
Ahmad, 1984:
In a reproduction test with Daphnia magna, a 28 E50 of 0.36-0.6 mg/L was determined.
Referenceopen allclose all
EU Risk Assessment (2003):
Reported NOEC range between 0.064 mg/l (US EPA, 1988) and 0,36 mg/l (Richter et al., 1983). Values for EC50 range between 0,.6 mg/l (Hermens et al., 1984) and 0.45 mg/l (Calamari et al., 1983).
The daphnia test by Calamari et al. (1983) was performed under semi-static conditions (test medium changed every other day), in a closed system and the measured concentration did not deviate more than 15% from the initial concentration.
In a study by Hermens et al. (1984) on the sublethal toxicity to Daphnia magna, the 16-day LC50 on mortality was 0.56 mg/l and the EC50 on reproduction was 0.27 mg/l (reported asµmol/l inthe reference). In an identical 16-day experiment, measurements of the test concentrations are stated to average 58% of nominal (Hermens et al., 1985) and the 16-day EC50 was 0.52 mg/l.The results are not corrected for the measured concentrations. Assuming the average concentration was the same in the two experiments, the 16 -day LC50 was 0.32 mg/l, EC50 0.16 mg/l and the NOEC on mortality and reproduction 0.19 mg/l and 0.06 mg/l, respectively. The corrected values are reported in the table above.
BUA report (1987):
The most critical reported NOEC for Daphnia is 0.1 mg/l for the extended life cycle test (Hermens et al., 1984).
Description of key information
For transported isolated intermediates according to REACh, Article 18, this endpoint is not a data requirement. However, data is available for this endpoint and is thus reported under the guidance of "all available data".
Generally, following NOEC values have been reported for the long-term toxicity to aquatic invertebrates:
NOEC: 0.064 - 0.7 mg/L
BUA report, 1987:
The most critical reported NOEC for Daphnia is 0.1 mg/l for the extended life cycle test (Hermens et al., 1984).
EU Risk Assessment, 2003:
Reported NOEC range between 0.064 mg/l (US EPA, 1988) and 0.36 mg/l (Richter et al., 1983). Values for EC50 range between 0.6 mg/l (Hermens et al., 1984) and 0.45 mg/l (Calamari et al., 1983).
The daphnia test by Calamari et al. (1983) was performed under semi-static conditions (test medium changed every other day), in a closed system and the measured concentration did not deviate more than 15% from the initial concentration.
In a study by Hermens et al. (1984) on the sublethal toxicity to Daphnia magna, the 16-day LC50 on mortality was 0.56 mg/l and the EC50 on reproduction was 0.27 mg/l (reported asµmol/l inthe reference).
In an identical 16-day experiment, measurements of the test concentrations are stated to average 58% of nominal (Hermens et al., 1985) and the 16-day EC50 was 0.52 mg/l.The results are not corrected for the measured concentrations. Assuming the average concentration was the same in the two experiments, the 16 -day LC50 was 0.32 mg/l, EC50 0.16 mg/l and the NOEC on mortality and reproduction 0.19 mg/l and 0.06 mg/l, respectively.
Yoshioka, 1993:
In a reproduction test conducted OECD Guideline 211 and OECD Guideline 202, part 2 with Daphnia magna, a 21 d-NOEC of 0.7 mg/L was determined.
Ahmad, 1984:
In a reproduction test with Daphnia magna, a 28 E50 of 0.36-0.6 mg/L was determined.
NITE Japan, 2009
In a reproduction test, with Daphnia magna a 21 d NOEC of 0.1 mg/L and a 21 d EC50 of 0.1 - 0.32 mg/L were determined.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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