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Diss Factsheets
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EC number: 204-428-0 | CAS number: 120-82-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- other: not specified if calculated or experimental result
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original reference is not available.
- GLP compliance:
- not specified
- Executive summary:
Rippen, 1991
pH = 9 kB < 10e-4 L mol(e-1) h(e-1); half-life > 1 a
1,2,4-Trichlorobenzene will not hydrolyze under environmental conditions.- Endpoint:
- hydrolysis
- Type of information:
- other: scientific judgement
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original reference is not available.
- GLP compliance:
- not specified
- Executive summary:
Howard, 1991
t1/2: 3.4 years, scientific judgement based upon overall rate constant (2.3 x 10e-5 he-1) at pH 7 and 25 °C (Ellington, J.J. et al. 1988)
- Endpoint:
- hydrolysis
- Type of information:
- other: BUA report
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Executive summary:
BUA report (1987):
1,2,4-trichlorobenzene is not hydrolysable under the conditions existing in the environment.
- Endpoint:
- hydrolysis
- Type of information:
- other: not specified if calculated or experimental result
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original reference is not available.
- GLP compliance:
- not specified
- Executive summary:
Umweltbundesamt (UBA), 1986
t1/2 pH 3: 1806 h at 50 °C
t1/2 pH 7: 4577 h at 50 °C
t1/2 pH 9: 6889 h at 50 °C- Endpoint:
- hydrolysis
- Type of information:
- other: EU Risk Assessment
- Adequacy of study:
- other information
- Reliability:
- other: EU Risk Assessment
- Rationale for reliability incl. deficiencies:
- other: No reliability is given as this is a summary entry for the EU RAR.
- GLP compliance:
- not specified
- Executive summary:
EU Risk Assessment (2003):
EU RAR, page: 24
Based on the experimental data (Korte and Freitag, 1986) on hydrolysis at 50°C,1,2,4-TCB is not expected to hydrolyse under normal environmental conditions (Howard, 1989; Schmidt-Bleek et al., 1982).
EU RAR, page: 8
The hydrolysis was studied in buffer solutions at pH 3, 7 and 9 using radioactive 1,2,4-TCB at the initial concentration of 17.7 mg/l. During a study period of 5 days, the half-lives of 1,2,4 TCB at 50°C were estimated to be 1,806 hours (75 days) at pH 3, 4,577 hours (190 days) at pH 7 and 6,889 hours (287 days) at pH 9 (Korte and Freitag, 1986). The large half-lives for hydrolysis which indicate hydrolytic stability mean that it has not been taken into account in the risk assessment.
Referenceopen allclose all
t1/2: 3.4 years
BUA report (1987):
1,2,4-trichlorobenzene is not hydrolysable under the conditions existing in the environment.
Description of key information
For transported isolated intermediates according to REACh, Article 18, this endpoint is not a data requirement. However, data is available for this endpoint and is thus reported under the guidance of "all available data".
EU Risk Assessment (2003):
EU RAR, page: 24
Based on the experimental data (Korte and Freitag, 1986) on hydrolysis at 50°C,1,2,4-TCB is not expected to hydrolyse under normal environmental conditions (Howard, 1989; Schmidt-Bleek et al., 1982).
EU RAR, page: 8
The hydrolysis was studied in buffer solutions at pH 3, 7 and 9 using radioactive 1,2,4-TCB at the initial concentration of 17.7 mg/l. During a study period of 5 days, the half-lives of 1,2,4 TCB at 50°C were estimated to be 1,806 hours (75 days) at pH 3, 4,577 hours (190 days) at pH 7 and 6,889 hours (287 days) at pH 9 (Korte and Freitag, 1986). The large half-lives for hydrolysis which indicate hydrolytic stability mean that it has not been taken into account in the risk assessment.
BUA report (1987):
1,2,4-trichlorobenzene is not hydrolysable under the conditions existing in the environment.
Howard, 1991:
t1/2: 3.4 years, scientific judgement based upon overall rate constant (2.3 x 10e-5 he-1) at pH 7 and 25 °C (Ellington, J.J. et al. 1988)
Rippen, 1991:
pH = 9 kB < 10e-4 L mol(e-1) h(e-1); half-life > 1 a
1,2,4-Trichlorobenzene will not hydrolyze under environmental conditions.
Umweltbundesamt (UBA), 1986:
t1/2 pH 3: 1806 h at 50 °C
t1/2 pH 7: 4577 h at 50 °C
t1/2 pH 9: 6889 h at 50 °C
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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