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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Short description of key information on bioaccumulation potential result: 
Absorption:
Cinnamaldehyde is easy absored within the body rapidly and further distributed in various organs
Distribution:
Radioactivity is distributed primarily to the gastrointestinal tract, kidneys, and liver, after single- or multiple-dose oral administration. At all dose levels, a small amount of the dose is distributed to the fat.
Metabolism:
In the high dose pretreatment group, benzoic acid is the major metabolite, suggesting that saturation of the glycine conjugation pathway occurs at repeated high dose levels of cinnamaldehyde.
Excretion:
After 24 hr, >80% of the radioactivity is recovered in the urine and <7% in the feces from all groups of rats, regardless of dose level.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

Absorption:

Cinnamaldehyde is easy absored within the body rapidly and further distributed in various organs

Distribution:

Radioactivity is distributed primarily to the gastrointestinal tract, kidneys, and liver, after single- or multiple-dose oral administration. At all dose levels, a small amount of the dose is distributed to the fat.

Metabolism:

In the high dose pretreatment group, benzoic acid is the major metabolite, suggesting that saturation of the glycine conjugation pathway occurs at repeated high dose levels of cinnamaldehyde.

Excretion:

After 24 hr, >80% of the radioactivity is recovered in the urine and <7% in the feces from all groups of rats, regardless of dose level.