Registration Dossier
Registration Dossier
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EC number: 203-213-9 | CAS number: 104-55-2
Toxicity to reproduction
Administrative data
- Endpoint:
- multi-generation reproductive toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- other: Authoritative data base
- Title:
- HSDB Number 209
- Year:
- 2 011
- Bibliographic source:
- HSDB (Hazardous Substances Data Bank); US national Library of Medicine reviewed by SRC
- Reference Type:
- other: Authoritative data base
- Title:
- No information
- Year:
- 2 012
- Bibliographic source:
- NTP (National Toxicological Program)by Agency for Toxic Substances and Disease Registry; Division of Toxicology/Toxicology Information Branch, 1600 Clifton Road NE, E-29, Atlanta, Georgia 30333
- Reference Type:
- other: Authoritative data base
- Title:
- No information
- Year:
- 2 011
- Bibliographic source:
- ACToR(Aggregated Computational Toxicology Resource)Mantovani, A.,Stazi, A.V.,Macri,C.,Ricciardi,C.,Piccioni,A.andBadellino,W.(1989).Pre-Natal(Segment II) Tox.Study of Cinnamic Aldehyde in the Sprague-Dawley Rats.Food and Chemical Toxico.27(12): 781-786.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Cinnamic aldehyde was administered by gavage to Sprague-Dawley rats on days 7-17 of pregnancy at doses of 5, 25 or 250 mg/kg/day.Test Type: Pre-Natal (Segment II) Toxicity Study.Duration of test: Days 7-17 of pregnancy
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cinnamaldehyde
- EC Number:
- 203-213-9
- EC Name:
- Cinnamaldehyde
- Cas Number:
- 104-55-2
- Molecular formula:
- C9H8O
- IUPAC Name:
- 3-phenylacrylaldehyde
- Test material form:
- liquid: viscous
- Details on test material:
- - Name of test material (as cited in study report): cinnamaldehyde
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- olive oil
Doses / concentrations
- Remarks:
- Doses / Concentrations:
5, 25 or 250 mg/kg/day
Basis:
no data
Examinations
- Parental animals: Observations and examinations:
- No signs of maternal toxicity observed
- Statistics:
- Statistical evaluations: Kruskal-Wallis test, Mann-Wittney test
Results and discussion
Results: P0 (first parental generation)
Details on results (P0)
Results: F1 generation
Details on results (F1)
Results: F2 generation
Effect levels (F2)
- Dose descriptor:
- LOAEL
- Generation:
- F2
- Effect level:
- 5 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- female
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Administration of Cinnamaldehyde to pregnant rats resulted in increased incidence of poor cranial ossification and reduced ossification of the tympanic bulla. Significant increases of the incidences of dilated pelvis/reduced papilla in the kidney, ureters > 2 abnormal sternebrae per fetus were also reported.
- Executive summary:
Cinnamaldehyde was administered by gavage to Sprague-Dawley rats on days 7-17 of pregnancy at doses of 5, 25 or 250 mg/kg/day. Test carried out for duration 7-17 days of pregnancy. Offspring toxicity F1 and F2 showed increased incidence of poor cranial ossification, decreased ossification of tympanic bulla at 25 or 250 mg/kg/day, increased incidence of dilated pelvis/reduced papilla in kidney, increased incidence of reduced cranial ossification, dilated ureter. However,No signs of maternal toxicity observed. The lowest observed adverse effect level (LOAEL) found to be 5 mg/kg bw/day
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