Registration Dossier
Registration Dossier
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EC number: 215-200-5 | CAS number: 1312-81-8
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1963
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- The Acute Mammalian Toxicity of Rare Earth Nitrates and Oxides
- Author:
- Bruce D W, Hietbrink BE, Du Bois K P
- Year:
- 1 963
- Bibliographic source:
- Toxicology and Applied Pharmacology 5, 750-759
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Five or 10 female Sprague-Dawley rats received a single i.p. dose of 1000 mg/kg bw of Lanthanum oxide as a 50% suspension in an aqueous solution of 0.2% carboxymethylcellulose. The animals were oberved for 30 days for clinical signs of toxicity and mortality.
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- Lanthanum oxide
- EC Number:
- 215-200-5
- EC Name:
- Lanthanum oxide
- Cas Number:
- 1312-81-8
- Molecular formula:
- La2O3
- IUPAC Name:
- lanthanum(3+);oxygen(2-)
- Details on test material:
- - Name of test material (as cited in study report): Lanthanum oxide
- Substance type: inorganic oxide
- Physical state: solid
- Analytical purity: > 98%
- Impurities (identity and concentrations): not given
- Source: St. Eloi Corporation, Cincinnati, Ohio
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Not stated
- Age at study initiation: adult rats
- Weight at study initiation: 190 to 250 g
- Housing: air conditioned, no further data
- Diet: ad libitum: Rockland Rat diet
- Water: ad libitum
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on exposure:
- The test substance was administered by i.p. administration of a 50% suspension (homogenized) in carboxymethycellulose 0.2% in water.
- Doses:
- 1000 mg/kg bw
- No. of animals per sex per dose:
- 5 or 10 females
- Control animals:
- not specified
- Details on study design:
- Five or 10 female Sprague-Dawley rats received a single oral dose of 1000 mg/kg bw of Lanthanum oxide i.p. as a 50% suspension in an aqueous solution of 0.2% carboxymethylcellulose. The animals were oberved for 30 days for clinical signs of toxicity and mortality.
Results and discussion
- Mortality:
- No treatment related mortality throughout the 30 d observation period.
- Clinical signs:
- Not reported
- Body weight:
- Not reported
- Gross pathology:
- Not reported
Any other information on results incl. tables
The acute LD50 after intraperitoneal administration to female Sprague-Dawley rats was above 1000 mg/kg bw.
Applicant's summary and conclusion
- Conclusions:
- Lanthanium oxide did not cause mortality in female Sprague-Dawley rats after single i.p. administration of 1000 mg lanthanum oxide/kg bw.
- Executive summary:
Lanthanium oxide did not cause mortality in female Sprague-Dawley rats after single i.p. administration of 1000 mg lanthanum oxide/kg bw.
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