Butyl 2,3-epoxypropyl ether

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1956

Report date:

1956

Materials and methods

Principles of method if other than guideline:

To evaluate the acute toxicity, groups of 5 mice were given graded doses (400, 800, 1600, and 3200 mg/kg bw) of the test substance, followed by a 10 day observation period.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Butyl 2,3-epoxypropyl ether

EC Number:

219-376-4

EC Name:

Butyl 2,3-epoxypropyl ether

Cas Number:

2426-08-6

Molecular formula:

C7H14O2

IUPAC Name:

2-(butoxymethyl)oxirane

Test material form:

liquid

Specific details on test material used for the study:

Name as sited in report: Butyl glycidyl ether (BGE)

Test animals

Species:

mouse

Strain:

other: Princeton

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Hooper Foundation
- Weight at study initiation: 16-22 gram
- Housing: 5 to a cage
- Diet: Special green powdered diet obtained from the Simonsen Laboratories.

Administration / exposure

Route of administration:

other: intragastrically

Vehicle:

propylene glycol

Details on oral exposure:

Exposure by means of ball-point needle and syringe.

VEHICLE
- Concentration in vehicle: 20%

Doses:

400, 800, 1600, and 3200 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

The animals were held for a 10-day observation period after treatment, during which mortality records were kept and weight changes recorded. Surviving animals were sacrificed for necropsy. Animals were decapitated under light ether anaesthesia. Suitable tissues were taken for histological examination from all moribund animals and animals that died during laboratory hours.

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

1 530 mg/kg bw

Based on:

test mat.

95% CL:

>= 1 170 - <= 2 000

Mortality:

At 400 mg/kg bw: No mortality occurred
At 800 mg/kg bw: No mortality occurred.
At 1600 mg/kg bw: 3/5 animals died. Death occurred within 7-15 hours.
At 3200 mg/kg bw: All animals died. Death occurred within 5 minutes.

Gross pathology:

Animals subjected to necropsy showed no gross abnormalities. Histologic examination revealed severe pulmonary congestion in two cases and one case of focal inflammatory cells in the liver.

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria