Butyl 2,3-epoxypropyl ether

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1956

Report date:

1956

Materials and methods

Principles of method if other than guideline:

Groups of 5 rats were exposed to graded concentrations of the test substance for 8 hours.

GLP compliance:

no

Test type:

traditional method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Butyl 2,3-epoxypropyl ether

EC Number:

219-376-4

EC Name:

Butyl 2,3-epoxypropyl ether

Cas Number:

2426-08-6

Molecular formula:

C7H14O2

IUPAC Name:

2-(butoxymethyl)oxirane

Test material form:

liquid

Specific details on test material used for the study:

Name as sited in report: Butyl glycidyl ether (BGE)

Test animals

Species:

rat

Strain:

Long-Evans

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Simonsen Laboratories (California)
- Weight at study initiation: 110 to 140 gram.
- Housing: 5 to a cage
- Diet: Special green powdered diet obtained from the Simonsen Laboratories.

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

A motor driven syringe delivered measured amounts of the test substance from a 10 mL Luer-Lok syringe into an evaporator through which metered air moved at a uniform rate. High concentration was obtained by bubbling air through a fritted glass disc immersed in the compound, which was held in a glass container. The rate of airflow was set at approximately 5 liters per minute, for concentrated vapors, and at 3 to 11 liters per minute for the graded concentrations. Nominal concentrations were calculated by the standard gas-concentration formula of Jacobs (1949) and were checked by determining the total quantity of material vaporized.

Duration of exposure:

8 h

Concentrations:

670, 1000, 1500, and 2300 ppm

No. of animals per sex per dose:

5

Control animals:

no

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

LC50

Effect level:

1 030 ppm

Based on:

test mat.

95% CL:

>= 890 - <= 1 240

Exp. duration:

8 h

Mortality:

At 670 ppm: No mortality occurred.
At 1000 ppm: 1/5 animals died. Death occurred within 16 hours.
At 1500 ppm: 5/5 animals died. Death occurred within 6-11 hours.
At 2300 ppm: 5/5 animals died. Death occurred within 1-14 days.

Clinical signs:

other: Depression with little activity was noted in rats exposed to 670 ppm. Rats huddled at the side of the chamber away from the vapour inlet. At 1000 ppm, their activity varied from extreme apathy to agitation and leaping at the chamber walls. Dyspnea was pre

Gross pathology:

The test substance caused distended stomachs and intestines; one rat had a ruptured stomach and distended enteric tract. Congestion was observed in the abdominal cavity, and the lungs had a mottled appearance. Microscopic examination of the rats that died showed only pulmonary congestion and autolysis of the gastric mucosa.