Registration Dossier
Registration Dossier
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EC number: 242-354-0 | CAS number: 18472-51-0
Endpoint summary
Administrative data
Description of key information
Additional information
Chlorhexidine digluconate is a white crystalline powder with neutral odour. However, the substance is produced and handled only as 20% aqueous solution which is colourless or pale-yellowish.
The melting point of solid Chlorhexidine digluconate was detected to be 53°C in a study according to OECD 102. The substance decomposes before boiling at approximately 157°C. The relative density of solid Chlorhexidine Digluconate has been determined to 1.3778 at 20°C, while the relative density of the 20% solution has been determined to 1065 kg/m3at 20°C. The vapour pressure of solid Chlorhexidine digluconate has been determined to 5.1E-5 hPa at 25°C.
In a test according to OECD 107 (Shake Flask Method) the octanol/water partition coefficient of Chlorhexidine digluconate has been determined to -1.81 at 20.7°C.The log POW increases with increasing pH. The water solubility of Chlorhexidine digluconate has been determined to >=75,0% (m/m) at 20°C. In aqueous solution, Chlorhexidine digluconate will dissociate completely at relevant pH values forming double protonated Chlorhexidine and single deprotonated Gluconic acid.
Addition of alcohols or acetone to the 20% aqueous solution leads to precipitations. At a concentration of 0.59 % in water, CHx-gluconate forms micelles and reduces the surface tension of water to ca. 50 mN/m. The kinematic viscosity of Chlorhexidine digluconate solution (20%) has been determined to 2.51 mm2/s (20°C), while the dynamic viscosity has been determined to 2.67E-3 kg/m s (20°C).
The substance is produced, handled and marketed only as aqueous solution which is not flammable or explosive. From the structural formula and the composition of the substance it can be safely concluded that the substance does not evolve any oxidizing properties.
Chlorhexidine digluconate has been demonstrated to be stable towards hydrolysis and non-reactive towards container material. From this and from its structural formula it can be concluded that the active substance is non-reactive towards the solvents used in the b.p. (1-propanol, 2-propanol, ethanol) and will be stable. Compatible container materials for the 20% solution are: Hostalen GM 6255 and Lupolen 4261 AGUV.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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