Registration Dossier
Registration Dossier
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EC number: 242-354-0 | CAS number: 18472-51-0
Biodegradation in water and sediment: simulation tests
Administrative data
Link to relevant study record(s)
Description of key information
The route and rate of degradation of chlorhexidine digluconate was investigated under aerobic conditions at 20 ± 2ºC in two contrasting water sediment systems in the dark (according to OECD308). Chlorhexidine digluconate was shown to degrade to unextractable sediment bound residues and minor metabolites only, with only 4-Chloroaniline being identified.Transfer of chlorhexidine digluconate from the water into the sediment was rapid with DT50 values of 1.4 and 4.1 days in the two systems tested. The rate of degradation in the total water/sediment systems was however slow, with DT50 values of
>1000 and 277 days for Calwich Abbey and Swiss Lake systems, respectively.
In conclusion, Chlorhexidine digluconate was proven to be poorly biodegradable and is considered “not biodegradable” in the present risk assessment.
Key value for chemical safety assessment
Additional information
Most of the available studies used isolated bacteria strains, the tests were run under laboratory conditions. The results from these non-Guideline tests allow neither a classification of biodegradability, nor a conclusion about degradation rates in biological treatment plants and in environmental compartments.
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