Registration Dossier
Registration Dossier
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EC number: 242-354-0 | CAS number: 18472-51-0
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- The Direct Peptide Reactivity Assay: Selectivity of Chemical Respiratory Allergens
- Author:
- Lalko JF, Kimber I, Gerberick GF, Foertsch LM, Api AM & Dearman RJ
- Year:
- 2 012
- Bibliographic source:
- Toxicological Sciences 129(2): 421–431
Materials and methods
- Type of sensitisation studied:
- respiratory
- Study type:
- other: direct peptide reactivity assay (DPRA)
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Chlorhexidine was tested in the direct peptide reactivity assay (DPRA) and failed to react with either peptide. Therefore, chlorhexidine was judged as a nonsensitizing substance.
- Executive summary:
Chlorhexidine was tested in the direct peptide reactivity assay (DPRA), i.e. known skin and respiratory sensitizers were reacted with synthetic peptides containing either lysine (Lys) or cysteine (Cys) for 24 h. The samples were analysed by HPLC/UV, and the loss of peptide from the reaction mixture was expressed as the percent depletion compared with the control. The potential for preferential reactivity was evaluated by comparing the ratio of Lys to Cys depletion (Lys:Cys ratio). Chlorhexidine failed to react with either peptide. Based on previous experience, depletion of less than 10% is typically associated with nonsensitizing chemicals or, in some cases, pre-/prohaptens.
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